Using alveolar bone tissue to diagnose early-stage osteoporosis : The establishment of a dentistry-based technique-

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The present study used bone biopsy samples extracted during dental implant preparation, for investigating microstructural changes in alveolar cancellous bone due to menopause, and elucidating relationships between these changes and bone turnover markers.In the alveolar cancellous bone, bone volume was found to be significantly less in late postmenopausal group than in premenopausal group. In early postmenopausal group, trabecular separation and structure model index (SMI) were significantly higher than in premenopausal group. Each alveolar bone parameter was significantly related to at least one bone turnover marker. The present study therefore revealed changes in alveolar cancellous bone structure even in early postmenopausal women, and also that this structure varies in close relationship to bone turnover markers.