Effect of Prosthetic Treatment on Stress Biomarker Level of Maxillary Bone Resected Patients during Sleep

修复治疗对上颌骨切除患者睡眠期间应激生物标志物水平的影响

• 批准号: 16591946
• 负责人: NISHIGAWA Goro
• 金额: $ 2.24万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591946/
• 关键词: QOL; mental stress; stress biomarker; speech difficulty; oral cancer; saliva; prosthesis; health; ストレス・マーカー; 腫瘍摘出手術; 発語明瞭度

The aim of this study is to examine the effect of prosthetic treatment on the salivary stress biomarker level of oral cancer patient. Sixteen patients were selected as subjects with partial maxillary bone defects. Prosthetic treatment with removable obturator was served to all subjects at Okayama University Hospital. The salivary Chromogranin A (CgA) were measured as salivary stress biomarkers during speech with prosthesis. To sixteen conventional denture wearers (for control), sampling of saliva was performed just before and after same speech intelligibility test. Speech intelligibility test score, visual analogue scale (VAS) satisfactory score and health scores were measured with and without prosthesis.The increase of salivary CgA level caused by speech test with prosthesis showed significantly higher value than the value without prosthesis (p<0.016). No significant differences were observed between those of the control group.The speech intelligibility test score and VAS satisfactory score showed the effectiveness of the prosthesis.From these results, it was suggested that the patients after oral cancer surgery still have mental stress even if the speech ability was recovered with prosthesis.

本研究的目的是检查口腔癌患者修复治疗对唾液应激生物标志物水平的影响。选择16例患者作为部分上颌骨缺损的受试者。在冈山大学医院，所有受试者都接受了可拆卸闭孔器的假体治疗。检测患者戴修复体发音过程中唾液嗜铬粒蛋白A（CgA）的变化。对16名传统义齿佩戴者（作为对照），在相同的语言清晰度测试之前和之后进行唾液采样。分别测量两组患者的语音清晰度测试评分、视觉模拟评分（VAS）满意度评分和健康状况评分，结果显示，两组患者的唾液CgA水平差异有统计学意义（P<0.016）。结果表明，口腔癌术后患者在使用人工修复后，即使恢复了语言能力，但仍存在心理压力。

项目成果

Remnant vinyl polysiloxane fitness test material on alloy surface decrease adhesive strength between alloy and luting material.

合金表面残留的乙烯基聚硅氧烷适应性测试材料降低了合金与粘合材料之间的粘合强度。

• 发表时间: 2005
• 期刊: The Second International Congress on Adhesive Dentistry
• 作者: Nishigawa G;Maruo Y;Okamoto M;et al.
• 通讯作者: et al.

精神的ストレスと歯根膜外力認知閾値との関連

精神压力与牙周膜外力识别阈值的关系

• 发表时间: 2005
• 期刊: 口腔顔面痛懇談会第6回研究会(The 10^<th> Japan Academy of Orofaclal Pain共催学術集会)
• 作者: 沖 和広;洲脇道弘;西川悟郎;他
• 通讯作者: 他

Effect of adhesive primer developed exclusively for heat-curing resin on adhesive strength between plastic artificial tooth and acrylic denture base resin.

专为热固化树脂开发的粘合底漆对塑料假牙与丙烯酸义齿基托树脂之间粘合强度的影响。

• 发表时间: 2006
• 期刊: Dental Materials Journal 25,1
• 作者: Nishigawa G;Maruo Y;Okamoto M;et al.
• 通讯作者: et al.

Adhesive primer for adhesion between plastic tooth and heat-curing resin.

用于粘合塑料牙齿和热固化树脂之间的粘合底漆。

• 发表时间: 2006
• 期刊: American association for dental research Special issue
• 作者: Nishigawa;G.;Maruo;Y.;Okamoto;M.(他4名)
• 通讯作者: M.(他4名)

顎義歯装着者の発音時における唾液中ストレス指標物質の動態

上颌义齿佩戴者言语过程中唾液压力指示物质的动态

• 发表时间: 2006
• 期刊: 日本補綴歯科学会学会雑誌 第115回抄録集
• 作者: 鵜川由紀子;酒川悟郎;丸尾幸憲;他
• 通讯作者: 他