A research on the quantitative analysis of brain lesions caused by hypertension and diabetes mellitus with MRI.

1.大脑解剖变化我们报告了与年龄匹配的正常对照相比，慢性疲劳综合征患者中发现的灰质和白色变化的定量分析结果（见参考文献）。基于此方法，对高血压和糖尿病患者的变化进行分析。然而，由于这些患者的缺血性脑变化，该分析方法不能直接应用。因此，我们现在正在分析脑血管狭窄或闭塞患者的脑图像，这些患者具有轻度缺血性改变，并且正在准备出版的手稿。2.脑代谢变化我们首先研究了用MR波谱法测量脑代谢物的可重复性。我们发现肌醇的重现性和信噪比之间存在线性关系。这一结果在加拿大多伦多举行的美国神经放射学会第43<rd>届年会上发表。这是一个新的结果，并撰写了一篇论文，正在提交中。3.脑灌注变化在脑灌注分析中，方法本身是非常重要的。我们使用分析软件Dr.View 2.0/Linux（AsahiKasei Jyoho System，Inc.）对脑灌注进行了研究。该软件于2006年初进行了修订，实现了全自动分析，使分析更加客观。有了这个新引进的系统，我们正在重新分析测试-再测试脑灌注数据，并准备提交论文。我们也正在做一个比较研究的脑灌注测量与MRI与PET的准确性进行评估。

1.Brain anatomical changesWe reported a result of quantitative analysis of gray and white matter changes found in patients of chronic fatigue syndrome compared with age-matched normal controls (see Bibliography). Based on this method, the analysis of the changes in patients of hypertension and diabetes mellitus were analyzed. Owing to ischemic brain changes in these patients, however, the analysis method is not directly applicable. Hence, we are now analyzing brain images of patients with cerebrovascular stenosis or occlusion, who have mild ischemic changes and are preparing a manuscript for publication.2.Brain metabolitic changesWe firstly investigated the reproducibility of metabolite measurements of the brain with MR spectroscopy. We found a linear relationship in myoinositol between reproducibility and signal-to-noise ratio. This result was reported at the American Society of Neuroradiology 43^<rd> Annual Meeting at Toronto, Canada. This is a novel result and a paper was written and is under submission.3.Brain perfusion changesIn the analysis of brain perfusion, the method itself is of large importance. We had been researched on the brain perfusion with the analysis software, Dr.View 2.0/Linux (AsahiKasei Jyoho System, Inc.). This software was revised at early 2006 and enabled fully automatic analysis, that enables more objective analysis. With this newly introduced system, we are reanalyzing test-retest brain perfusion data and preparing a paper for submission. We are also making a comparative study of the brain perfusion measurement with MRI vs.PET for the evaluation of the accuracy.