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A research on the quantitative analysis of brain lesions caused by hypertension and diabetes mellitus with MRI.

高血压、糖尿病脑损伤的MRI定量分析研究

基本信息

批准号：
16615007
负责人：
OKADA Tomohisa
金额：
$ 1.6万
依托单位：
Institute of Biomedical Research and Innovation
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16615007/
关键词：
Magnetic Resonance Imaging Hypertension Diabetes Mellitus

项目摘要

1.Brain anatomical changesWe reported a result of quantitative analysis of gray and white matter changes found in patients of chronic fatigue syndrome compared with age-matched normal controls (see Bibliography). Based on this method, the analysis of the changes in patients of hypertension and diabetes mellitus were analyzed. Owing to ischemic brain changes in these patients, however, the analysis method is not directly applicable. Hence, we are now analyzing brain images of patients with cerebrovascular stenosis or occlusion, who have mild ischemic changes and are preparing a manuscript for publication.2.Brain metabolitic changesWe firstly investigated the reproducibility of metabolite measurements of the brain with MR spectroscopy. We found a linear relationship in myoinositol between reproducibility and signal-to-noise ratio. This result was reported at the American Society of Neuroradiology 43^<rd> Annual Meeting at Toronto, Canada. This is a novel result and a paper was written and is under submission.3.Brain perfusion changesIn the analysis of brain perfusion, the method itself is of large importance. We had been researched on the brain perfusion with the analysis software, Dr.View 2.0/Linux (AsahiKasei Jyoho System, Inc.). This software was revised at early 2006 and enabled fully automatic analysis, that enables more objective analysis. With this newly introduced system, we are reanalyzing test-retest brain perfusion data and preparing a paper for submission. We are also making a comparative study of the brain perfusion measurement with MRI vs.PET for the evaluation of the accuracy.

1.大脑解剖学变化我们报告了慢性疲劳综合征患者与年龄匹配的正常对照组相比灰质和白质变化的定量分析结果（参见参考文献）。以此方法为基础，对高血压、糖尿病患者的变化进行分析。然而，由于这些患者的缺血性脑部变化，该分析方法并不直接适用。因此，我们现在正在分析脑血管狭窄或闭塞患者的脑部图像，这些患者有轻度缺血性改变，并正在准备发表手稿。2.脑代谢变化我们首先研究了用磁共振波谱法测量脑部代谢物测量的再现性。我们发现肌醇的重现性和信噪比之间存在线性关系。这一结果在加拿大多伦多举行的美国神经放射学会第 43 届年会上报告。这是一个新颖的结果，一篇论文已经完成并正在提交。3.脑灌注变化在脑灌注分析中，方法本身非常重要。我们使用分析软件Dr.View 2.0/Linux（AsahiKasei Jyoho System, Inc.）对脑灌注进行了研究。该软件于2006年初进行了修订，实现了全自动分析，从而使分析更加客观。通过这个新引入的系统，我们正在重新分析重测脑灌注数据并准备提交论文。我们还对 MRI 与 PET 的脑灌注测量进行了比较研究，以评估准确性。