Ein Ernährungsmuster zur Flavonolaufnahme als Risikofaktor für Pankreaskrebs in der Multiethnic Cohort Study und der EPIC-Studie

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In my previous work I have reported an inverse association between flavonols, which are a group of polyphenols ubiquitous in plant foods, and the risk of pancreatic cancer. The potential pancreatic cancer preventive effect of flavonols is an important and new finding, which now (a) has to be transferred to the level of foods to ease public health recommendations, and (b) to be confirmed in independent studies.The proposed research project aims at doing both with a unique international approach. First, a food pattern associated with flavonols should be determined in the prospective Multiethnic Cohort Study (MEC) in the USA, in which I originally observed the inverse association of flavonols and pancreatic cancer. To derive the food pattern the reduced rank regression (RRR) approach will be applied which has recently been introduced by our group in Potsdam as a promising tool to derive hypothesis driven dietary patterns in nutritional epidemiology. To confirm the findings the food pattern should subsequently be applied to and investigated in the European EPIC (European Prospective Investigation into Cancer and Nutrition) – Study, which I am lately conducting pancreatic cancer research in. The outstanding quality of this approach is the combination of two large prospective studies. The EPIC-Study itself would be unable to examine this association at this point due to the lack of flavonols in food composition tables. This application refers to the work to be done in the MEC.