Upregulation of Auaporin-1 in experimental hydocephalus ameliorated with shunting

作者研究了水通道蛋白(AQP)-1和4在高岭土诱导的大鼠脑积水中的表达。高岭土注射后2、4、9周，AQP-1mRNA在脉络丛和脑底均有表达，并随着脑室扩张而逐渐增强。AQP-1的蛋白在相同的时间进程和相同的部位表达，但不会逐渐增加。脑脊液分流术后，该基因和蛋白均下调。在整个时间过程中，任何脑组织中都没有检测到AQP-4mRNA及其蛋白的表达。本研究表明，高岭土诱导的实验性脑积水导致AQP-1的基因和蛋白表达，而不是AQP-4的表达。AQP-1的表达可能是为了对抗脑脊液循环障碍引起的停滞。AQP-1调节可能在脑积水的治疗中继续发挥新的作用。

The author investigated the expression of aquaporin (AQP) -1 and 4 in kaolin-induced hydrocephalus in rats. The induction of AQP-1 mRNA was observed in the choroids plexus and at the cerebral base 2, 4, and 9 weeks after the injection of kaolin, and gradually increased in tandem with the development of ventricular dilatation. The protein for AQP-1 was expressed within the same time course and at the same sites but did not augment incrementally. Both of the gene and protein down regulated after cerebrospinal fluid (CSF) shunting. The expression of either AQP-4 mRNA or its protein was not detected in any brain tissue throughout the time course. The present study showed that experimental hydrocephalus induced by kaolin caused the gene and protein for AQP-1 to be expressed, but not AQP-4. The expression of AQP-1 may be evoked to counteract stagnation caused by impairment of the CSF circulation. AQP-1 regulation may continue to play a new role in the treatment of hydrocephalus.