前列腺癌进展相关基因的鉴定及其在治疗中的应用-猫眼课题宝

前列腺癌进展相关基因的鉴定及其在治疗中的应用

批准号：

17591669

负责人：

MIZOKAMI Atsushi

金额：

$2.24万

依托单位：

Kanazawa University

依托单位国家：

日本

项目类别：

Grant-in-Aid for Scientific Research (C)

财政年份：

2005

资助国家：

日本

项目状态：

已结题

起止时间：

2005 至 2006

来源：

https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591669/

关键词：

prostate cancer androgen-dependent VEGF cDNA microarray ホルモン非依存性

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中文摘要

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英文摘要

1.We established androgen-independent prostate cancer cell lines, LN-REC4 and LNCaP-SF from LNCaP cells.2.These cells grew very well when they were inoculated in castrated scid mouse subcutaneously. One of this reason was speculated that increased VEGF secretion.3.We identified genes that were regulated by DHT by cDNA microarray analysis. (screened 16,785 genes).4.We confirmed that these genes were really regulated by DHT by RT-PCR.5.There were 374 and 581 genes in LNCaP and up-regulated by DHT and 623 and 388 genes down-regulated genes. 105 genes were down-regulated genes in both cell lines.

期刊论文(2)

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会议论文

Establishment and characterization of androgen-independent human prostate cancer cell lines, LN-REC4 and LNCaP-SF, from LNCaP

DOI： 10.1111/j.1442-2042.2007.01532.x

发表时间： 2007-03-01

期刊：

INTERNATIONAL JOURNAL OF UROLOGY

影响因子： 2.6

作者：

[Iwasa, Yoichi, Mizokami, Atsushi, Namiki, Mikio]