動脈硬化症との類似性からみた尿路結石症の成因の研究:特に転写因子NF-κBの関与

在岩石形成和动脉硬化方面，它们的形成过程是相似的。我们研究了脂肪细胞因子作为动脉硬化因子是否与尿路结石的形成有关。特别是，脂联素剂量依赖性地抑制巨噬细胞对上皮细胞的粘附。脂联素抑制TNF - a的磷酸化，通过增加I-κB间接抑制NF-K - B，从而抑制MФ的粘附。采用草酸盐前体腹腔给药建立尿石症小鼠模型。进一步探讨了与代谢综合征相关的脂肪细胞因子是否参与了产石过程。推测脂联素在尿路产石中起重要作用。并通过高脂饮食2个月建立肥胖大鼠。给药后第7天肾尿小管管腔扩张。在草酸盐前体乙二醇被喂给这些大鼠后，大量的结石被识别出来，而在喂食正常饲料的大鼠中，这些钙化无法被识别出来。从我们的研究结果来看，肥胖促进了尿路结石的发生。

On lithogenesis and arteriosclerosis, their formation processes are similar. We examined whether adipocytokine noticed as an arteriosclerotic factor was concerned in urinary stone formation. Especially, adiponectine dose-dependently inhibits the adhesion of macrophage to epithelial cells. Adiponectine inhibits the phosphorylation of TNF a, and the adhesion of MФ has been inhibited by indirectly suppressing NF-K B by increasing I-κB. We established urolithiasis model mouse by intraabdominal administration of oxalate precursor. Furthermore, whether adipocytokine which is concerned in metabolic syndrome by this process was concerned in lithogenesis was examined. It is guessed that adiponectine has an important role for lithogenesis in urinary tract.And, the obesity rat was established by administration of the high fat diet for 2 months. The renal uriniferous tubule lumen was expanded on administration post-seventh days. After the ethylene glycol which was the oxalate precursor was administered to these rats, large number of calculi were recognized, and in the rat which administered a normal feed, these calcification could not be recognized. From our results, it was proven that the obesity promoted lithogenesis in urinary tract.