動脈硬化症との類似性からみた尿路結石症の成因の研究:特に転写因子NF-κBの関与

从与动脉硬化的相似性角度研究尿石症的发病机制:特别是转录因子NF-κB的参与

基本信息

  • 批准号:
    17591691
  • 负责人:
  • 金额:
    $ 1.98万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2005
  • 资助国家:
    日本
  • 起止时间:
    2005 至 2006
  • 项目状态:
    已结题

项目摘要

On lithogenesis and arteriosclerosis, their formation processes are similar. We examined whether adipocytokine noticed as an arteriosclerotic factor was concerned in urinary stone formation. Especially, adiponectine dose-dependently inhibits the adhesion of macrophage to epithelial cells. Adiponectine inhibits the phosphorylation of TNF a, and the adhesion of MФ has been inhibited by indirectly suppressing NF-K B by increasing I-κB. We established urolithiasis model mouse by intraabdominal administration of oxalate precursor. Furthermore, whether adipocytokine which is concerned in metabolic syndrome by this process was concerned in lithogenesis was examined. It is guessed that adiponectine has an important role for lithogenesis in urinary tract.And, the obesity rat was established by administration of the high fat diet for 2 months. The renal uriniferous tubule lumen was expanded on administration post-seventh days. After the ethylene glycol which was the oxalate precursor was administered to these rats, large number of calculi were recognized, and in the rat which administered a normal feed, these calcification could not be recognized. From our results, it was proven that the obesity promoted lithogenesis in urinary tract.
关于成石和动脉硬化,它们的形成过程是相似的。我们检查了作为动脉硬化因子的脂肪细胞因子是否与尿路结石形成有关。特别是,脂联素剂量依赖性地抑制巨噬细胞与上皮细胞的粘附。脂联素抑制 TNF a 的磷酸化,并通过增加 I-κB 间接抑制 NF-K B,从而抑制 MФ 的粘附。我们通过腹腔注射草酸前体建立尿石症模型小鼠。此外,还研究了通过该过程与代谢综合征有关的脂肪细胞因子是否与成石有关。推测脂联素对于泌尿道的结石形成具有重要作用。并且,通过给予2个月的高脂肪饮食来建立肥胖大鼠。第七天后,肾输尿管管腔扩张。在给这些大鼠施用作为草酸盐前体的乙二醇后,发现大量结石,而在施用正常饲料的大鼠中,无法发现这些钙化。从我们的结果来看,肥胖促进了泌尿道的结石形成。

项目成果

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TOZAWA Keiichi其他文献

TOZAWA Keiichi的其他文献

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{{ truncateString('TOZAWA Keiichi', 18)}}的其他基金

Anti-NF-kB reagents for prevention of urinary stone
预防尿路结石的抗 NF-kB 试剂
  • 批准号:
    22591797
  • 财政年份:
    2010
  • 资助金额:
    $ 1.98万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The application of the transcription factor related to urinary stone formation to elucidation and gene therapy
尿路结石形成相关转录因子在阐明及基因治疗中的应用
  • 批准号:
    14571513
  • 财政年份:
    2002
  • 资助金额:
    $ 1.98万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
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