Anti-NF-kB reagents for prevention of urinary stone

预防尿路结石的抗 NF-kB 试剂

• 批准号: 22591797
• 负责人: TOZAWA Keiichi
• 金额: $ 2.91万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591797/
• 关键词: 尿路結石; アヂポサイトカイン; 転写因子; 生活習慣病; 尿路結石症; NF-κB; マクロファージ; 酸化; RANK-RANKL; 転写因子NF-κB; オステオポンチン; IKKα阻害剤; IKKβ阻害剤

The present lifestyle causes lifestyle-related diseases, such as diabetes, hyperlipidemia, hypertension, and arteriosclerosis, through fat accumulation and overweight. In this research, it showed clearly that the gene expression of adipocytokines relates to the morbidity of a urinary stone disease, and proved that the application to medical treatment is possible. Furthermore, the cytokine promotes adhesion molecules and NF-kappa B-RANK- RANKL signal, and so progress of arteriosclerosis. Same signal transduction inquired by considering that urolithiasis formation is also carrying out the same mechanism. The correlation to urinary stone formation of a RANK- RANKL signal transfer system was not able to be proved.NF-kappa B was activated by many extracellular stimuli, such as oxidant stress. Then, activation of inflammatory cytokine and a macrophage was promoted and it was checked that NF-kappa B plays an important role for urolithiasis formation.

目前的生活方式通过脂肪积累和超重引起与生活方式相关的疾病，如糖尿病、高脂血症、高血压和动脉硬化。本研究清楚地表明脂肪细胞因子的基因表达与泌尿系结石病的发病有关，并证明其应用于医疗是可能的。此外，细胞因子促进粘附分子和NF-κ B-RANK- RANKL信号，从而促进动脉硬化的进展。考虑到尿石症的形成也在进行着同样的机制，探讨了同样的信号转导。RANK- RANKL信号传递系统与尿路结石形成的相关性尚不能得到证实。NF-κ B B可被多种细胞外刺激激活，如氧化应激。然后，促进了炎性细胞因子和巨噬细胞的活化，并证实NF-κ B在尿石形成中起重要作用。

项目成果

尿路結石症の危険因子と謬療への応用

尿石症的危险因素及其在医疗中的应用

• 发表时间: 2010
• 作者: 長谷川政徳、宮嶋哲;他5名;宮 明;黒松 功;戸澤啓一
• 通讯作者: 戸澤啓一

泌尿器科レジデントマニュアル(監修 郡 健二郎、編集 佐々木 昌一、戸澤 啓一、丸山 哲史)

泌尿外科住院医师手册（健次郎监修，佐佐木翔一、户泽敬一、丸山聪编）

• 发表时间: 2011
• 作者: 高橋久弥､高橋正幸;小森政嗣;香川純一郎;仙崎智一;布川朋也;武村政彦;山本恭代;山口邦久;中逵弘能;井崎博文;福森知治;金山博臣;佐々木昌一
• 通讯作者: 佐々木昌一

Mitocondrial permeability transition pore opening induces the initial process of renal calcium crystallization.

线粒体通透性转变孔开放诱导肾钙结晶的初始过程。

• 发表时间: 2012
• 期刊: Free Rad Biol & Med
• 作者: 小坂威雄、宮嶋哲;他5名;新美和寛
• 通讯作者: 新美和寛

Role of osteopontin in early phase of renal crystal formation: immunohistochemical and microstructural comparisons with osteopontin knock-out mice

• DOI: 10.1007/s00240-011-0400-z
• 发表时间: 2012-04-01
• 期刊: UROLOGICAL RESEARCH
• 作者: Hirose, Masahito;Tozawa, Keiichi;Kohri, Kenjiro
• 通讯作者: Kohri, Kenjiro