Anti-NF-kB reagents for prevention of urinary stone

目前的生活方式通过脂肪积累和超重引起与生活方式相关的疾病，如糖尿病、高脂血症、高血压和动脉硬化。本研究明确了脂肪细胞因子的基因表达与泌尿系结石病的发病有关，证明了其在医学上的应用是可能的。此外，细胞因子促进粘附分子和NF-κ B-RANK- RANKL信号，从而促进动脉硬化的进展。考虑到尿石症的形成也在进行着同样的机制，探讨了同样的信号转导。RANK- RANKL信号传递系统与尿路结石形成的相关性尚不能得到证实。NF-κ B B可被多种细胞外刺激激活，如氧化应激。然后，促进了炎性细胞因子和巨噬细胞的活化，并证实NF-κ B在尿石形成中起重要作用。

The present lifestyle causes lifestyle-related diseases, such as diabetes, hyperlipidemia, hypertension, and arteriosclerosis, through fat accumulation and overweight. In this research, it showed clearly that the gene expression of adipocytokines relates to the morbidity of a urinary stone disease, and proved that the application to medical treatment is possible. Furthermore, the cytokine promotes adhesion molecules and NF-kappa B-RANK- RANKL signal, and so progress of arteriosclerosis. Same signal transduction inquired by considering that urolithiasis formation is also carrying out the same mechanism. The correlation to urinary stone formation of a RANK- RANKL signal transfer system was not able to be proved.NF-kappa B was activated by many extracellular stimuli, such as oxidant stress. Then, activation of inflammatory cytokine and a macrophage was promoted and it was checked that NF-kappa B plays an important role for urolithiasis formation.