Analysis of Prognostic Factors in Head and Neck Squamous Cell Carcinoma Patients Treated with Docetaxel and Concurrent Radiotherapy

多西紫杉醇同步放疗头颈鳞癌患者预后因素分析

• 批准号: 17591773
• 负责人: ORIDATE Nobuhiko
• 金额: $ 2.24万
• 依托单位: HOKKAIDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591773/
• 关键词: Head and neck cancer; docetaxel; Radiation therapy; Prognostic factors; Molecular markers; 頭頚部癌; ドセタキセル; 再発予測因子

The semi-synthetic taxane, docetaxel, has demonstrated significant anti-tumor activity in head and neck squamous cell carcinoma (HNSCC) and is thought to enhance tumor radiosensitivity. However, molecular markers that might be of use in pre icting the prognosis and sensitivity of HNSCC patients to docetaxel and radiotherapy treatment have not yet been reported. The current study aimed to address this issue and evaluate the significance of the cell-cycle-control proteins cyclin D1 and p16 as prognostic markers. Cyclin D1 and/or p16 protein expression was retrospectively evaluated by immunohistochemistry in 53 head and neck cancer patients who were treated with 10 mg/m2/week docetaxel four to six times and received concurrent chemoradiotherapy (total radiation therapy dose 65-66 Gy) over a 6.5-8 week period. Kaplan-Meier univariate analysis revealed that patients with cyclin D1-positive tumors or p16-negative tumors had a worse prognosis compared with those with cyclin Dl-negative tumors or p16-positive tumors (p=0.0004 and p=0.025, respectively). The prognostic significance of cyclin D1 expression was also confirmed using a proportional hazard regression model.

半合成紫杉烷，多西他赛，已被证明在头颈部鳞状细胞癌（HNSCC）中具有显着的抗肿瘤活性，并被认为可增强肿瘤的放射敏感性。然而，可能用于预测HNSCC患者预后和对多西他赛和放射治疗敏感性的分子标志物尚未报道。目前的研究旨在解决这个问题，并评估细胞周期控制蛋白cyclin D1和p16作为预后标志物的意义。通过免疫组化对53例头颈部癌患者的细胞周期蛋白D1和/或p16蛋白表达进行回顾性评价，这些患者接受10 mg/m2/周多西他赛治疗4 - 6次，并在6.5-8周内接受同步放化疗（总放疗剂量65-66戈伊）。Kaplan-Meier单变量分析显示，与cyclin D1阴性或p16阳性肿瘤患者相比，cyclin D1阳性或p16阴性肿瘤患者的预后较差（分别为p=0.0004和p=0.025）。还使用比例风险回归模型证实了细胞周期蛋白D1表达的预后意义。

项目成果

Laryngeal zoster mimicking a laryngeal cancer

类似喉癌的喉带状疱疹

• 发表时间: 2005
• 期刊: Otolaryngol Head Neck Surg. 133
• 作者: Higuchi E;Nakamaru Y;Ohwatari R;Sakashita T;Mesuda Y;Homma A;Furuta Y;Fukuda S.
• 通讯作者: Fukuda S.

"Watch-and-see" policy for theclinically positive neck in head and neck cancer treated withchemoradiotherapy

头颈癌放化疗临床阳性的“观望”政策

• 发表时间: 2006
• 期刊: Int J Clin Oncol 11・6
• 作者: Homma;A.;et al.
• 通讯作者: et al.

Prognostic significance of cyclin dl and p16 in patients with intermediate risk head and neck squamous-cell carcinoma treated with docetaxel and concurrent radiotherapy.

周期蛋白 dl 和 p16 对接受多西他赛和同步放疗的中危头颈鳞状细胞癌患者的预后意义。

• 期刊: Head and Neck (in press)
• 作者: Higuchi E;Oridate N;Homma A;Suzuki F;Atago Y;et al.
• 通讯作者: et al.

Prognostic significance of cyclin D1 and p16 in patients with intermediate-risk head and neck squamous cell carcinoma treated with docetaxel and concurrent radiotherapy

• DOI: 10.1002/hed.20632
• 发表时间: 2007-10-01
• 期刊: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
• 影响因子: 2.9
• 作者: Higuchl, Eisaku;Oridate, Nobuhiko;Fukuda, Satoshi
• 通讯作者: Fukuda, Satoshi

Rapid superselective high-dose cisplatin infusion with concomitant radiotherapy for advanced head and neck cancer

• DOI: 10.1002/hed.20116
• 发表时间: 2005-01-01
• 期刊: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
• 影响因子: 2.9
• 作者: Homma, A;Furuta, Y;Fukuda, S
• 通讯作者: Fukuda, S