Control and Activity of the Streptomyces Spore Wall Synthesizing Complex (SSSC) (A02)

链霉菌孢子壁合成复合物 (SSSC) 的控制和活性 (A02)

• 批准号: 48902398
• 金额: --
• 依托单位: Lehrstuhl für Mikrobiologie / Biotechnologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2007
• 资助国家: 德国
• 起止时间: 2006-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/48902398?language=en
• 关键词: Control; Activity; Streptomyces; Spore; Wall

During the life cycle of antibiotic producing streptomycetes the hyphae are septated into chains of more than 50 spores in a highly synchronized manner. The Streptomyces spore wall synthesizing complex SSSC, which resembles the elongasome of rod-shaped bacteria has a key role in this process. We want to elucidate how the Streptomyces spore wall synthesizing complex SSSC achieves the synthesis of peptidoglycan and anionic glycopolymers and how protein phosphorylation controls the coordination of the SSSCs.

在产生抗生素的链霉菌的生命周期中，菌丝以高度同步的方式分隔成超过 50 个孢子的链。链霉菌孢子壁合成的复合物SSSC类似于杆状细菌的延长体，在此过程中发挥着关键作用。我们想要阐明链霉菌孢子壁合成复合物SSSC如何实现肽聚糖和阴离子糖聚合物的合成以及蛋白质磷酸化如何控制SSSC的协调。