Investigating chromosome movement during meiotic prophase I

研究减数分裂前期 I 期间的染色体运动

• 批准号: 490729328
• 负责人: Professor Dr. Arp Schnittger
• 金额: --
• 依托单位: Biozentrum Klein Flottbek und Botanischer Garten
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/490729328?language=en
• 关键词: Investigating; chromosome; movement; during; meiotic

Meiosis is a key step in reproduction during which homologous recombination not only ensures genome stability (DNA repair, correct segregation of the homologous chromosomes in gametes) but also promotes genetic diversity (generation of new allelic combinations). Already many years ago, it was recognized that meiotic chromosomes are highly mobile and their movements have been implicated in recombination. However, due to the lack of appropriate imaging set up, little is known about chromosome dynamics. In their preparatory work, the partners of this initiative have established a system to follow Arabidopsis thaliana chromosomes in real time. In addition, this consortium unites researchers experienced in quantitative image analysis and modeling next to experts in meiotic recombination and cytogenetics studies. Combining these expertises will allow us to describe chromosome dynamics in meiosis with unprecedented resolution and assess its importance for recombination.

减数分裂是生殖过程中的关键步骤，在此过程中，同源重组不仅保证了基因组的稳定性(DNA修复、同源染色体在配子中的正确分离)，而且还促进了遗传多样性(产生新的等位基因组合)。早在许多年前，人们就认识到减数分裂染色体具有高度的移动性，它们的运动与重组有关。然而，由于缺乏适当的成像设置，对染色体动力学知之甚少。在他们的准备工作中，这一倡议的合作伙伴建立了一个实时跟踪拟南芥染色体的系统。此外，该联盟还联合了在定量图像分析和建模方面经验丰富的研究人员，与减数分裂重组和细胞遗传学研究的专家并驾齐驱。结合这些专业知识将使我们能够以前所未有的分辨率描述减数分裂中的染色体动力学，并评估其对重组的重要性。