Locomotion of parasitic nematodes in the gut: movement in viscoelastic mucus intertwined with the metabolic activity of the nematodes

肠道内寄生线虫的运动：粘弹性粘液的运动与线虫的代谢活动交织在一起

• 批准号: 492009137
• 负责人: Professorin Dr. Susanne Hartmann
• 金额: --
• 依托单位: Deutsches Rheuma-Forschungszentrum Berlin (DRFZ)
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/492009137?language=en
• 关键词: Locomotion; parasitic; nematodes; gut; movement

Gastrointestinal nematodes are globally distributed and highly prevalent in humans and animals. Considerable knowledge exists on the dispute of nematodes with their host’s immune system. But only marginal knowledge is available on the locomotion of adult worms in the host gut, the interlink with the gut mucus as well as the energy household and defense metabolism of the parasites. Therefore, in the proposed project we aim to focus on i) how do adult worms locomote in the gut against the flow of the small intestine and why do they locomote to the proximal part of the gut? ii) Which roles do mucus viscosity and flowing properties play for parasite locomotion and do mucus properties change during infection? Is mucus permeable for nematode components? And finally, iii) how is nematode locomotion linked to the energy household metabolism of the worms? Is nematode motility correlated to metabolic defense mechanisms of the parasite and against which niche component is this defense activity directed? In conclusion, with the proposed project we aim to elucidate mechanisms of nematode locomotion in the host gut and to understand the linkage to the viscoelastic properties of the gut mucus and metabolic activities of the worms.

胃肠道线虫在全球范围内分布，在人类和动物中高度流行。关于线虫与宿主免疫系统之间的争议，存在相当多的知识。但是，只有边缘的知识是可利用的蠕虫在宿主肠道中的运动，与肠道粘液的相互联系，以及能量家庭和防御代谢的寄生虫。因此，在拟议的项目中，我们的目标是集中在i）蠕虫如何在肠道中对抗小肠的流动，以及为什么它们会移动到肠道的近端部分？ii）粘液粘度和流动特性对寄生虫运动起什么作用，感染期间粘液特性是否发生变化？粘液对线虫成分有渗透性吗？最后，iii）线虫的运动与蠕虫的能量代谢有何联系？线虫运动与寄生虫的代谢防御机制相关吗？这种防御活动针对哪个生态位成分？总之，与拟议的项目，我们的目标是阐明线虫运动在宿主肠道的机制，并了解肠道粘液的粘弹性和蠕虫的代谢活动的联系。