Role of sex hormones on microbiome, immunity, and coronary microvascular dysfunction and rarefication in experimental HFpEF (A05)

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HFpEF is more often diagnosed in women, especially post menopause, but who on average face less effective care. We hypothesize sex differentially in HFpEF reflect 1) sex steroid impact directly or indirectly on gut microbiome, circulating metabolites, or immune system; in turn acting through 2) coronary microvascular dysfunction. Applying multi-omics technologies to animal models of HFpEF where endocrine sex can be manipulated, we will test this hypothesis and determine its specific microbial, immune and molecular drivers. Findings will be projected into the human setting by integrative and comparative analysis of host-microbiome data from this CRC and other sources.