Molecular mechanism of synaptic plasticity

脂质诱导物(前列腺素、白三烯、血小板活化因子等)的各种酶和受体。已经被分离出来，他们的基因敲除小鼠是由该项目的成员建立的。通过分析它们的表型，发现这些介质参与了大脑功能、突触发生和神经细胞发育，与谷氨酸和其他神经递质协同工作。我们还发现了突触传递和可塑性过程中不同类型的激酶(蛋白激酶C、钙钙调素依赖的激酶、MAP激酶等)的调节。几种小分子GTP结合蛋白及其相关分子(SNARE、CREB)在突触可塑性中的作用已被确定。

Various enzymes and receptors for lipid niediators (prostaglandins, leukotrines, platelet-activating factor etc.) have been isolated and their knockout mice were established by the members of this project. By analyzing their phenotypes, it was found that these mediators arc involved in brain functions, synaptogeneses, and neuronal cell development, working in concert with glutamate and other neurotransmitters. we also identified regulations of various types of kinases (protein kinases C, calcium calmodulin-dependent kinases, MAP kinases etc) during synaptic transmission and plasticity. Several small sized GTP binding proteins, and related molecules (SNARE, CREB) are identified of their roles in the synaptic plasticity.