Functional Development of Neural Circuits

神经回路的功能发育

• 批准号: 07279102
• 负责人: TSUMOTO Tadaharu
• 金额: $ 57.66万
• 依托单位: Osaka University Graduate School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-07279102/
• 关键词: Brain; Neural Circuits; Development; Neuron; Synapse; Differentiation; Growth; Plasticity; 長期増強

This project addressed a question of how neural circuits are formed and functionally developed so as to execute the higher brain function. To elucidate mechanisms underlying the formation and functional development of neural circuits in the brain, we took multidisciplinary approaches in this project. Thus, a close collaboration among researchers with different methodologies was essential for success of this project. After such a collaboration among members of this research project, we succeeded in obtaining many excellent results which were published in top-rank international journals. In this fiscal year we have edited a report of their achievements including a list of their publications. This report has been sent to researchers who are working in related fields and the members of this research project.

这个项目解决了一个问题，即神经回路是如何形成和功能发展的，从而执行更高的大脑功能。为了阐明大脑中神经回路形成和功能发展的潜在机制，我们在这个项目中采取了多学科的方法。因此，采用不同方法的研究人员之间的密切合作对该项目的成功至关重要。经过项目成员的通力合作，取得了多项优秀成果，并在国际一流期刊上发表。在本财政年度，我们编辑了一份关于它们的成就的报告，其中包括它们的出版物清单。本报告已发送给在相关领域工作的研究人员和该研究项目的成员。

项目成果

Kinoshita,S.,Yasuda,H.,Taniguchi,N.et al.: "Brain-derived neurotrophic factor prevents low-frequency inputs from inducing long-term depression in the developing visual cortex." J.Neuroscience. 19. 2122-2130 (1999)

Kinoshita,S.、Yasuda,H.、Taniguchi,N.等人：“脑源性神经营养因子可防止低频输入在发育中的视觉皮层中诱发长期抑郁。”

Allen, C., Jiang, Z., Teshima, K., Darland, T., Ikeda, M. et al.: "Orphanin-FQ (OFQ) modulates the activity of suprachiasmatic nucleus neurons"J. Neuroscience. 19. 2152-2160 (1999)

Allen, C.、Jiang, Z.、Teshima, K.、Darland, T.、Ikeda, M. 等人：“Orphanin-FQ (OFQ) 调节视交叉上核神经元的活动”J.

Akaneya,T., Tsumoto,T., Kinoshita,S. and Hatanaka,H.: "Brain derived neurotrophic factor enhances long-term potentiation in rat visual cortex." J.Neurosci.17. 6707-6716 (1997)

赤谷 T.、津本 T.、木下 S.

Tsubokawa,H,,Oguro,K.,Robinsdon,H.P.C.,et al.: "Intracellular inositol 1,3,4,5-tetrakisphosphate enhances the calcium current in hippocampal CAl neurones of the gerbil followint transient forebrain ischaemia." J.Physiol.Lond.497. 67-78 (1996)

Tsubokawa, H,,Oguro,K.,Robinsdon,H.P.C.等人：“细胞内肌醇 1,3,4,5-四磷酸可增强沙鼠海马 CA1 神经元在短暂前脑缺血后的钙电流。”

Shirasaki,R.,Tamada,A.,Katsumata,R.et al.: "Guidance of cerebellofugal axons in the rat embryo: Directed growth toward the floor plate and subsequent elongation along the longitudinal axis." Neuron. 14. 961-972 (1995)

Shirasaki,R.、Tamada,A.、Katsumata,R.等人：“大鼠胚胎中小脑轴突的引导：向底板定向生长，并随后沿纵轴伸长。”