A role of membrane-associated proteins in synaptic Plasticity.

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In this project we attempted to see whether or not an expression of membrene-associated, Ca^<2+>/calmobulin-binding proteins, calspectin and 4.1-like protein, is related to developmental changes in the degree of synaptic plasticity in the rat visual cortex. Immunohistochemical stainings of these proteins demonstrated that their expressions in visual cortical neurons were most marked during 10-34 postnatal days and became very weak thereafter to the adult. Since synaptic plasticity in the visual cortex is known to be at the highest level during 10-34 days and very low in the matured cortex, the present results suggest that these membrane-associated proteins may play a role in synaptic plasticity in the developing visual cortex.