A role of membrane-associated proteins in synaptic Plasticity.

膜相关蛋白在突触可塑性中的作用。

• 批准号: 61480108
• 负责人: TSUMOTO Tadaharu
• 金额: $ 3.84万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-61480108/
• 关键词: Synaptic plasticity; Visual Cortex; Calspectin; Fodrin; Protein 4.1; Development; Cytoskeletal proteins; 免疫組織化学; 4.1蛋白質

In this project we attempted to see whether or not an expression of membrene-associated, Ca^<2+>/calmobulin-binding proteins, calspectin and 4.1-like protein, is related to developmental changes in the degree of synaptic plasticity in the rat visual cortex. Immunohistochemical stainings of these proteins demonstrated that their expressions in visual cortical neurons were most marked during 10-34 postnatal days and became very weak thereafter to the adult. Since synaptic plasticity in the visual cortex is known to be at the highest level during 10-34 days and very low in the matured cortex, the present results suggest that these membrane-associated proteins may play a role in synaptic plasticity in the developing visual cortex.

在这个项目中，我们试图了解在大鼠视皮层中，膜相关的Ca^2+/钙调蛋白结合蛋白、钙调蛋白和4.1样蛋白的表达是否与突触可塑性程度的发育变化有关。免疫组织化学染色结果表明，这些蛋白质在视皮层神经元中的表达在出生后10-34天最为显著，到成年后表达减弱。由于已知视皮层中的突触可塑性在10-34天期间处于最高水平，并且在成熟皮层中非常低，因此本研究结果表明，这些膜相关蛋白可能在发育中的视皮层中的突触可塑性中起作用。

项目成果

佐藤宏道 他: Journal of Neurophysiology. 58. 765-780 (1987)

Hiromichi Sato 等人：神经生理学杂志 58. 765-780 (1987)

Kimura, F. et al.: "Postnatal development of immunohistochemical localization of spectrin-like protein (Calspectin or Fodrin) in the rat visual cortex: Its excessive expression in developing cortical neurons." Journal of Neurocytology. 16. 649-665 (1987)

Kimura, F. 等人：“大鼠视觉皮层中血影蛋白样蛋白（Calspectin 或 Fodrin）的免疫组织化学定位的出生后发育：其在发育中的皮层神经元中过度表达。”

木村文隆: J.Neurocytology.

Fumitaka Kimura：J.神经细胞学。

津本忠治 他: Nature. 327. 513-514 (1987)

Tadaharu Tsumoto 等人：《自然》，327. 513-514 (1987)。

萩原幸一郎 他: Experimental Brain Research. 69. 407-416 (1988)

Koichiro Hagiwara 等人：实验脑研究 69. 407-416 (1988)