Administration of researches on principles of protein architecture

研究项目“蛋白质结构原理”在1995 -1998财政年度继续开展活动，目的是从进化和/或物理化学的角度解决“蛋白质三维结构和功能的信息如何编码在其氨基酸序列中”的问题。“当开始这个项目时，我们依赖于这样一个假设，即蛋白质折叠的种类仅限于相当小的数量，大约一千。基于这样的假设，我们设想了一个实现的蛋白质结构的预测使用的“线程”的方法。四年来的研究结果显示，在预测的实际目标方面取得了显著的进步，但没有取得明显的成功，这表明问题的本质是复杂的。通过组织这些前沿研究工作，我们为日本相关领域的激活做出了重大贡献。到我们每年组织的公开研讨会， ...更多信息 在1999财政年度，我们开展了一系列活动，整理了四年来的研究成果，并将其广泛传播给学术界和公众。特别是，我们（1）准备出版一本涵盖研究结果的专著，（2）组织了一次公开研讨会。(1)本研究成果作为日本最重要的综述性杂志之一《蛋白质、酶和核酸》的特刊进行了出版计划。我们举行了两次编辑会议，以讨论计划中的卷的基本概念。我们将很快向出版商提出出版建议。(2)首先，我们组织了一个公开研讨会，这是我们在资助科学研究期间每年组织的一系列研讨会的延续，今年6月14日也在神奈川县厅举行。讲习班非常活跃，有350多人参加。少

The research project, "Principle of Protein Architecture," has continued its activity during FY1995-1998 for the purpose of pursuing an evolutional and/or physicochemical solution to the question "how the information of protein's three dimensional structure and function is coded in its amino acid sequence."When starting this project, we had relied on the hypothesis that the variety of protein folds is limited to a rather small number, about one thousand. Based on such a hypothesis, we imagined a realization of the prediction of protein structures using the 'threading' method. The results of the research done for the four years show adual and significant improvements in terms of the practical goal of prediction, but with no clear-cut success, indicating the essentially complex nature of the problem.Together with organizing such forefront research efforts, we contributed significantly to the activation of the related fleldsin Japan. To the open workshop we organized annually, more than 4 … More 00 participants and more than 200 poster presentations were contributed.In FY1999, we carried out of activities of organizing the research results made during the four years and disseminating them widely to academic and more general public. In particular we (1) prepared publication of a monograph covering the research results, and (2) organized an open workshop. (1) We have carried out planning of publication of the research results as a special volume of "Protein, Enzyme and Nucleic Acid," which is one of the most important review journal in Japan. We had editorial meetings twice in order to discuss the basic concept of the planned volume. We will soon propose the publication to the publisher. (2) At first we organized an open workshop, which is a continuation of a series of symposia we have had organized annually during the tenure of the Grant-in-Aid Scientific Research, also this year on June 14 at Kanagawa Prefectural Hall. The workshop was very active, having more than 350 participants. Less