Administration of researches on principles of protein architecture

“蛋白质结构原理”研究项目在1995-1998财年继续进行，目的是寻求“蛋白质的三维结构和功能信息如何在其氨基酸序列中编码”这一问题的进化和/或物理化学解决方案。在开始这个项目的时候，我们依赖于一个假设，即蛋白质折叠的种类被限制在一个相当小的数量上，大约有1000种。基于这样的假设，我们设想了使用“穿线”方法预测蛋白质结构的实现。四年的研究结果表明，在预测的实际目标方面有了显著的进步，但没有明确的成功，这表明这个问题本质上是复杂的。在组织这些前沿研究工作的同时，我们为激活日本的相关领域做出了重大贡献。在我们每年举办的公开研讨会上，有超过400名参与者和200多张海报。1999财年，我们开展了整理四年研究成果并向学术界和社会广泛宣传的活动。特别是，我们(1)准备出版一本涵盖研究成果的专著，(2)组织了一次公开研讨会。(1)我们计划将研究成果作为日本最重要的评论期刊之一《蛋白质、酶和核酸》的专卷发表。我们举行了两次编辑会议，以讨论计划的卷的基本概念。我们将很快向出版商提议出版。(2)首先，我们组织了一个公开的研讨会，这是我们在科学研究补助金任期内每年组织的一系列专题讨论会的延续，今年也是6月14日在神奈川县厅举行。讲习班非常活跃，有350多人参加。少

The research project, "Principle of Protein Architecture," has continued its activity during FY1995-1998 for the purpose of pursuing an evolutional and/or physicochemical solution to the question "how the information of protein's three dimensional structure and function is coded in its amino acid sequence."When starting this project, we had relied on the hypothesis that the variety of protein folds is limited to a rather small number, about one thousand. Based on such a hypothesis, we imagined a realization of the prediction of protein structures using the 'threading' method. The results of the research done for the four years show adual and significant improvements in terms of the practical goal of prediction, but with no clear-cut success, indicating the essentially complex nature of the problem.Together with organizing such forefront research efforts, we contributed significantly to the activation of the related fleldsin Japan. To the open workshop we organized annually, more than 4 … More 00 participants and more than 200 poster presentations were contributed.In FY1999, we carried out of activities of organizing the research results made during the four years and disseminating them widely to academic and more general public. In particular we (1) prepared publication of a monograph covering the research results, and (2) organized an open workshop. (1) We have carried out planning of publication of the research results as a special volume of "Protein, Enzyme and Nucleic Acid," which is one of the most important review journal in Japan. We had editorial meetings twice in order to discuss the basic concept of the planned volume. We will soon propose the publication to the publisher. (2) At first we organized an open workshop, which is a continuation of a series of symposia we have had organized annually during the tenure of the Grant-in-Aid Scientific Research, also this year on June 14 at Kanagawa Prefectural Hall. The workshop was very active, having more than 350 participants. Less