Administration of researches on principles of protein architecture

“蛋白质结构原理”的研究项目在1995-1998财年期间一直在继续，目的是寻求进化和/或物理化学的解决方案，以解决“蛋白质的三维结构和功能的信息是如何在其氨基酸序列中编码的”这个问题。在启动这个项目时，我们依赖于这样一个假设，即蛋白质折叠的种类被限制在相当小的数量，大约1000个。基于这样的假设，我们设想了一种使用“穿线”方法预测蛋白质结构的实现。这四年的研究结果表明，在预测的实际目标方面有了明显的改善，但没有明确的成功，表明问题本质上是复杂的。通过组织这样的前沿研究努力，我们为激活日本的相关领域做出了重大贡献。到我们每年组织的开放研讨会，超过4…在1999财政年度，我们组织了四年来的研究成果，并向学术界和广大公众广泛传播。特别是，我们(1)准备出版一本涵盖研究成果的专著，(2)组织了一次公开研讨会。(1)以日本最重要的综述期刊之一的《蛋白质、酶和核酸》专册的形式进行了研究成果的出版策划。我们召开了两次编辑会，以讨论计划中的卷的基本概念。我们很快就会向出版商建议出版这本书。(2)我们首先组织了一次公开研讨会，这是我们在资助科学研究期间每年举办的一系列研讨会的继续，也是今年6月14日在神奈川县厅举行的。讲习班非常活跃，有350多人参加。较少

The research project, "Principle of Protein Architecture," has continued its activity during FY1995-1998 for the purpose of pursuing an evolutional and/or physicochemical solution to the question "how the information of protein's three dimensional structure and function is coded in its amino acid sequence."When starting this project, we had relied on the hypothesis that the variety of protein folds is limited to a rather small number, about one thousand. Based on such a hypothesis, we imagined a realization of the prediction of protein structures using the 'threading' method. The results of the research done for the four years show adual and significant improvements in terms of the practical goal of prediction, but with no clear-cut success, indicating the essentially complex nature of the problem.Together with organizing such forefront research efforts, we contributed significantly to the activation of the related fleldsin Japan. To the open workshop we organized annually, more than 4 … More 00 participants and more than 200 poster presentations were contributed.In FY1999, we carried out of activities of organizing the research results made during the four years and disseminating them widely to academic and more general public. In particular we (1) prepared publication of a monograph covering the research results, and (2) organized an open workshop. (1) We have carried out planning of publication of the research results as a special volume of "Protein, Enzyme and Nucleic Acid," which is one of the most important review journal in Japan. We had editorial meetings twice in order to discuss the basic concept of the planned volume. We will soon propose the publication to the publisher. (2) At first we organized an open workshop, which is a continuation of a series of symposia we have had organized annually during the tenure of the Grant-in-Aid Scientific Research, also this year on June 14 at Kanagawa Prefectural Hall. The workshop was very active, having more than 350 participants. Less