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Studies on Structure and Physical Properties of Poly (lactic acid)-Based Biodegradable Polyesters

聚乳酸基生物降解聚酯的结构与物理性能研究

基本信息

批准号：
11217209
负责人：
TSUJI Hideto
金额：
$ 8.83万
依托单位：
Toyohashi University of Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2002
项目状态：
已结题

项目摘要

The purposes of this study were(1)to develop new methods such as surface modification (alkaline treatment, biodegradable polymer coating), blending (hydrophilic biodegradable polymers, enantiomeric PLAs, and inorganic particles), and pore formation by the use of phase separation, to control physical properties and biodegradability of the poly (lactide) s [poly (lactic acid) s (PLAs)]-based biodegradable polyesters,(2)to investigate biodegradation mechanisms of the prepared materials, and(3)to develop a novel method for recycling PLAs to their monomers by the use of high-temperature and high-pressure water. It was found for biodegradable polyesters including PLAs that surface modification is effective both for acceleration and deceleration of their biodegradation without erosion of the core part of the materials, that blending is inclined to accelerate their biodegradation when the blends are phase-separated, and that pore formation is effective both for preparation of soft materials and acceleration of their biodegradation. Moreover, "restricted amorphous region" between the crystalline regions in spherulites was found to be much more hydrolysis-resistant than "free amorphous regions" outside spherulites and hydrolysis in the melt by the use of high-temperature and high-pressure water was shown to be a powerful method to recycling poly (L-lactide) [poly (L-lactic acid)] to L-lacticacid.

本研究的目的是（1）开发新的方法，如表面改性（碱性处理、可生物降解聚合物涂层）、共混（亲水性可生物降解聚合物、对映体PLA和无机颗粒）以及通过相分离形成孔，以控制聚丙交酯[聚乳酸]s的物理性能和生物降解性 (PLA)]基可生物降解聚酯，(2)研究所制备材料的生物降解机制，(3)开发一种利用高温高压水将PLA回收为其单体的新方法。研究发现，对于包括PLA在内的可生物降解聚酯，表面改性对于加速和减速其生物降解均有效，且不会侵蚀材料的核心部分；当共混物发生相分离时，共混倾向于加速其生物降解；而孔的形成对于软材料的制备和加速其生物降解均有效。此外，发现球晶中结晶区域之间的“受限非晶区域”比球晶外部“自由非晶区域”更耐水解，并且通过使用高温高压水在熔体中水解被证明是将聚(L-丙交酯)[聚(L-乳酸)]回收为L-乳酸的有效方法。