Summary of Molecular Methodology and Reaction Control of Oxygen Active Species

氧活性物质的分子方法学和反应控制综述

• 批准号: 11228204
• 负责人: FUKUZUMI Shunichi
• 金额: $ 6.4万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11228204/
• 关键词: Active Oxygen Complexes; Electron Transfer; SOD; Monooxygenase; Cytochrome; X-ray Crystal Structure; Metalloproteins; Hemerythrin; Oxygenation; 触媒化学; 物質・エネルギー変換; 反応制御法; エネルギー問題; 地球環境

The structures and reactivities of a variety of active oxygen-metal complexes have been revealed in relation with enzymatic oxidation reaction. A large number of information about metal-dioxygen reactivity has been accumulated, providing profound insight into the mechanism of O_2-binding and activation at metal reaction sites involved in many biological systems as well as in a variety of catalytic oxidation processes. In particular, reversible dioxygen binding (functional model of hemocyanim) has been accomplished using a series of dinucleating ligands. The present research project has provided valuable insight into the mechanisms of the four-electron reduction of oxygen as well as the four-electron oxidation of water. The initial objectives of the present research project have been well accomplished by the intensive cooperative research activities among seven research groups. The final results are summarized in the international symposium on the active oxygen-metal complexes held in january 2004, when the future prospect of the field of active oxygen-metal complexes has been discussed

揭示了与酶促氧化反应有关的各种活性氧-金属配合物的结构和反应活性。大量关于金属-分子氧反应性的研究积累了大量的信息，为深入了解许多生物体系中金属反应位点的O_2结合和活化机制以及各种催化氧化过程提供了重要的理论依据。特别是，可逆的双氧结合（血蓝蛋白的功能模型）已完成使用一系列双核配体。目前的研究项目提供了宝贵的洞察机制的四电子还原的氧以及四电子氧化的水。通过七个研究小组之间的密集合作研究活动，本研究项目的初步目标已经很好地完成。在2004年1月召开的活性氧金属配合物国际学术研讨会上，对研究结果进行了总结，并对活性氧金属配合物的发展前景进行了展望

项目成果

Shunichi Fukuzumi et al.: "100% Selective Oxygenation of p-Xylene to p-Tolualdehyde via Photoinduced Electron Transfer"Org.Lett.. 2・23. 3647-3650 (2000)

Shunichi Fukuzumi 等：“通过光诱导电子转移将对二甲苯 100% 选择性氧化为对甲苯甲醛”Org.Lett. 2・23 (2000)。

Watanabe,Y. et al.: "Formation and Catalytic Roles of Compound I in the Hydrogen Peroxide-Dependent Oxidations by His64 Myoglobin Mutants"J.Am.Chem.Soc.. 121・43. 9952-9957 (1999)

Watanabe，Y.等：“化合物I在His64肌红蛋白突变体的过氧化氢依赖性氧化中的形成和催化作用”J.Am.Chem.Soc.. 121·43（1999）。

Fukuzumi,S. et al.: "Porphyrin Handbook, Vol.8"Academic Press. 115-152 (1999)

福住，S.

Fukuzumi, S.et al.: "Catalytic Effects of Dioxygen on Intramolecular Electron Transfer in Radical Ion Pairs of Zinc Porphyrin-Linked Fullerenes"J.Am.Chem.Soc.. 123. 2571-2575 (2001)

Fukuzumi, S.et al.：“双氧对锌卟啉连接的富勒烯自由基离子对分子内电子转移的催化作用”J.Am.Chem.Soc.. 123. 2571-2575 (2001)

Itoh, S. ; Fukuzumi, S.et al.: "Aliphatic Hydroxylation by a Bis (μ-oxo) dinickel (III) Complex"J.Am.Chem.Soc.. 121. 8945-8946 (1999)

Itoh, S.；Fukuzumi, S.等：“双 (μ-氧) 二镍 (III) 复合物的脂肪族羟基化” J.Am.Chem.Soc.. 121. 8945-8946 (1999)