Genetic and Epigenetic Dysregulation in Cancer

癌症中的遗传和表观遗传失调

• 批准号: 16059101
• 负责人: NODA Tetsuo
• 金额: $ 17.86万
• 依托单位: Japanese Foundation For Cancer Research (2005-2009)Tohoku University (2004)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16059101/
• 关键词: 遺伝学; ウイルス; 癌; ゲノム; 細胞・組織; 遺伝子; 細胞組織; ウィルス

The research area for "Genetic and Epigenetic Dysregulation in Cancer" was organized to elucidate the molecular mechanisms for the process of cancer initiation and progression. This board for the research consists of section chiefs and leading investigators in this area and has been working to promote research activities of principle investigators through varied types of activity, such as the organization of researchers and the evaluation of their activities. We also organized workshops to promote information exchange among investigators. Our activity has substantially contributed for the promotion of research activity and the production of many novel scientific findings by investigators in the area.

“癌症的遗传和表观遗传失调”研究领域旨在阐明癌症发生和发展过程的分子机制。该研究委员会由该领域的科长和主要调查员组成，一直致力于通过组织研究员和评价其活动等各种活动促进主要调查员的研究活动。我们还举办了讲习班，以促进调查人员之间的信息交流。我们的活动大大促进了研究活动，并为该地区的研究人员提供了许多新的科学发现。

项目成果

RPA-like Mammalian Ctc1-Stn1-Ten1 Complex Binds to Single-Stranded DNA and Protects Telomeres Independently of the Pot1 Pathway

• DOI: 10.1016/j.molcel.2009.08.009
• 发表时间: 2009-10-23
• 期刊: MOLECULAR CELL
• 影响因子: 16
• 作者: Miyake, Yasuyuki;Nakamura, Mirai;Ishikawa, Fuyuki
• 通讯作者: Ishikawa, Fuyuki

Molecular mechanism of moderate insulin resistance in adiponectin-knockout mice.

• DOI: 10.1507/endocrj.k08e-093
• 发表时间: 2008-06
• 期刊: Endocrine journal
• 影响因子: 2
• 作者: Wataru Yano;N. Kubota;S. Itoh;Tetsuya Kubota;M. Awazawa;M. Moroi;K. Sugi;Iseki Takamoto;H. Ogata

Generation of multipotent stem cells from postnatal mouse testis.

从出生后小鼠睾丸中产生多能干细胞。

• 发表时间: 2004
• 期刊: Cell 119
• 作者: Kanatsu-Shinohara M.;Inoue K.;Lee J.;Yoshimoto M.;Ogonuki N.;Miki H.;Baba T.;Kazuki Y.;Toyokuni S.;Oshimura M.;Heike T.;Nakahata T.;Ishino F.;Ogura A.;Shinohara T
• 通讯作者: Shinohara T

Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation.

β-连环蛋白和 APC 的条件突变揭示了经典 Wnt 信号在晶状体分化中的作用。

• 发表时间: 2009
• 期刊: Invest.Ophthalmol.Vis.Sci.
• 作者: G.Martinez;T.Noda;et.al.(Total 8;6th/T.Noda)
• 通讯作者: 6th/T.Noda)

The selective continued linkage of centromeres through mitosis to interphase in the absence of mammalian separase.

在没有哺乳动物分离酶的情况下，着丝粒通过有丝分裂到间期选择性持续连接。

• 发表时间: 2006
• 期刊: J.Cell Biol. 172(6)
• 作者: K.Kumada;R.Yao;T.Kawaguchi;M.Karasawa;Y.Hoshikawa;K.Ichikawa;Y.Sugitani;I.Imoto;J.Inazawa;M.Sugawara;M.Yanagida;T.Noda.
• 通讯作者: T.Noda.