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Identification of molecular targets for cancer therapeutics through the analysis of tumor formation in mouse models for human carcinogenesis

Identification of molecular targets for cancer therapeutics through the analysis of tumor formation in mouse models for human carcinogenesis
通过分析人类致癌小鼠模型中的肿瘤形成来鉴定癌症治疗的分子靶点
批准号:
17013006
负责人:
NODA Tetsuo
金额:
$246.27万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009

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中文摘要
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英文摘要
In this study, we have developed several mouse models simulating the process of human carcinogenesis induced by the activation of oncogenic signaling such as Wnt and Sonic hedgehog signaling. Through the analysis of tumor formation in these mouse models, we could have successfully elucidated the molecular mechanisms of carcinogenesis. Functional roles of cancer related genes elucidated through this analysis could suggest strong candidates for novel molecular targets of human cancer therapy.
期刊论文(124)
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会议论文
Pancreatic cell mass preserved in heterozygous PDK1 knockout mice.
PDK1 杂合敲除小鼠中保存的胰腺细胞团。
DOI: --
发表时间: 2008
期刊: Kobe J. Med. Sci. 54
影响因子: --
作者: [A. Takeda, T. Noda et. al. (total 6, 5 th)]
通讯作者: 5 th)
Function of atypical protein kinase Clambda in differentiating photoreceptors is required for proper lamination of mouse retina.
非典型蛋白激酶 Clambda 在分化光感受器中的功能是小鼠视网膜正确分层所必需的。
DOI: --
发表时间: 2005
期刊: J.Neurosci. 25(44)
影响因子: --
作者: [C.Koike, T.Noda et al.(total 7, 5th)]
通讯作者: 5th)
ENU mutagenesis screening for dominant behavioral mutations based on normal control data obtained in home-cage activity, open-field, and passive avoidance tests.
ENU 诱变筛选基于在家笼活动、旷场和被动回避测试中获得的正常对照数据,用于显性行为突变的筛选。
DOI: --
发表时间: 2010
期刊: Exp.Anim.
影响因子: --
作者: [Y.Wada, T.Noda, et.al.(Total 13, 11th/T.Noda)]
通讯作者: 11th/T.Noda)
Phenotypic characterization of a new Grinl mutant mouse generated by ENU mutagenesis.
ENU 诱变产生的新 Grinl 突变小鼠的表型特征。
DOI: --
发表时间: 2010
期刊: Eur.J.Neurosci.
影响因子: --
作者: [T.Furuse, T.Noda, et.al.(Total 20, 18th/T.Noda)]
通讯作者: 18th/T.Noda)
87
    Comparison of Modularization in the Information Service Industry and Construction of the Productivity Analysis Model
    • 批准号:
      21530220
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.66万
    • 财政年份:
      2009
    • 负责人:
      NODA Tetsuo
    • 依托单位:
    Investigation of Actual Conditions of Introduction of Ubiquitous Network of Small and Medium-sized Enterprise and Theoretical Research in Effect of Network
    • 批准号:
      18530176
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $0.88万
    • 财政年份:
      2006
    • 负责人:
      NODA Tetsuo
    • 依托单位:
    Genetic and Epigenetic Dysregulation in Cancer
    Fuctinonal analysis of cancer related genes by targeted mutagenesis in mice
    • 批准号:
      12213009
    • 项目类别:
      Grant-in-Aid for Scientific Research on Priority Areas
    • 资助金额:
      $145.73万
    • 财政年份:
      2000
    • 负责人:
      NODA Tetsuo
    • 依托单位:
    海外基金