Identification of molecular targets for cancer therapeutics through the analysis of tumor formation in mouse models for human carcinogenesis

在这项研究中，我们开发了几种小鼠模型，模拟致癌信号，如Wnt和Sonic hedgehog信号激活诱导的人类致癌过程。通过分析这些小鼠模型中的肿瘤形成，我们可以成功地阐明致癌的分子机制。通过这种分析阐明的癌症相关基因的功能作用可能为人类癌症治疗的新分子靶点提供强有力的候选者。

In this study, we have developed several mouse models simulating the process of human carcinogenesis induced by the activation of oncogenic signaling such as Wnt and Sonic hedgehog signaling. Through the analysis of tumor formation in these mouse models, we could have successfully elucidated the molecular mechanisms of carcinogenesis. Functional roles of cancer related genes elucidated through this analysis could suggest strong candidates for novel molecular targets of human cancer therapy.