Identification of molecular targets for cancer therapeutics through the analysis of tumor formation in mouse models for human carcinogenesis

通过分析人类致癌小鼠模型中的肿瘤形成来鉴定癌症治疗的分子靶点

• 批准号: 17013006
• 负责人: NODA Tetsuo
• 金额: $ 246.27万
• 依托单位: Japanese Foundation For Cancer Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17013006/
• 关键词: 遺伝学; 遺伝子; 癌; ゲノム; シグナル; モデル動物; シグナル伝達

In this study, we have developed several mouse models simulating the process of human carcinogenesis induced by the activation of oncogenic signaling such as Wnt and Sonic hedgehog signaling. Through the analysis of tumor formation in these mouse models, we could have successfully elucidated the molecular mechanisms of carcinogenesis. Functional roles of cancer related genes elucidated through this analysis could suggest strong candidates for novel molecular targets of human cancer therapy.

在这项研究中，我们开发了几种小鼠模型，模拟致癌信号，如Wnt和Sonic hedgehog信号激活诱导的人类致癌过程。通过分析这些小鼠模型中的肿瘤形成，我们可以成功地阐明致癌的分子机制。通过这种分析阐明的癌症相关基因的功能作用可能为人类癌症治疗的新分子靶点提供强有力的候选者。

项目成果

Pancreatic cell mass preserved in heterozygous PDK1 knockout mice.

PDK1 杂合敲除小鼠中保存的胰腺细胞团。

• 发表时间: 2008
• 期刊: Kobe J. Med. Sci. 54
• 作者: A. Takeda;T. Noda et. al. (total 6;5 th)
• 通讯作者: 5 th)

Function of atypical protein kinase Clambda in differentiating photoreceptors is required for proper lamination of mouse retina.

非典型蛋白激酶 Clambda 在分化光感受器中的功能是小鼠视网膜正确分层所必需的。

• 发表时间: 2005
• 期刊: J.Neurosci. 25(44)
• 作者: C.Koike;T.Noda et al.(total 7;5th)
• 通讯作者: 5th)

ENU mutagenesis screening for dominant behavioral mutations based on normal control data obtained in home-cage activity, open-field, and passive avoidance tests.

ENU 诱变筛选基于在家笼活动、旷场和被动回避测试中获得的正常对照数据，用于显性行为突变的筛选。

• 发表时间: 2010
• 期刊: Exp.Anim.
• 作者: Y.Wada;T.Noda;et.al.(Total 13;11th/T.Noda)
• 通讯作者: 11th/T.Noda)

Phenotypic characterization of a new Grinl mutant mouse generated by ENU mutagenesis.

ENU 诱变产生的新 Grinl 突变小鼠的表型特征。

• 发表时间: 2010
• 期刊: Eur.J.Neurosci.
• 作者: T.Furuse;T.Noda;et.al.(Total 20;18th/T.Noda)
• 通讯作者: 18th/T.Noda)

An essential role of the universal polarity protein, aPKC1ambda, on the maintenance of podocyte slit diaphragms.

通用极性蛋白 aPKC1amda 在足细胞裂隙隔膜的维持中发挥着重要作用。

• 发表时间: 2009
• 期刊: PloS ONE 4
• 作者: T. Hirose;T. Noda et. al. (total 10;9 th)
• 通讯作者: 9 th)