Analysis on the spatio-temporal regulation of cellular oncogenesis

细胞肿瘤发生的时空调控分析

• 批准号: 17012014
• 负责人: MATSUDA Michiyuki
• 金额: $ 195.2万
• 依托单位: Kyoto University (2006-2009)Osaka University (2005)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17012014/
• 关键词: がん; FRETバイオセンサー; 蛍光イメージング; システム生物学; 細胞増殖因子; がん遺伝子; 上皮細胞増殖因子; Ras; MAPキナーゼ; Shoc2; FRET; 細胞増殖; Rac1; イノシトールリン脂質; Asef; G蛋白; セリンスレオニンキナーゼ; Akt; PI3キナーゼ; Raf; transformation; signal; transduction; simulation; 細胞増殖情報伝達系; シミュレーション; FR

We aimed at understanding the oncogene signal transduction network. For this purpose, we have developed biosensors based on the principle of fluorescence resonance energy transfer (FRET) and developed simulation models. These models will be bases of further improved simulation models, which allow us to draw the global picture of oncogene signal transduction network.

我们的目的是了解癌基因信号转导网络。为此，我们研制了基于荧光共振能量转移(FRET)原理的生物传感器，并建立了模拟模型。这些模型将是进一步改进仿真模型的基础，使我们能够绘制出癌基因信号转导网络的全局图景。

项目成果

Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth.

• DOI: 10.1083/jcb.200610073
• 发表时间: 2007-08-27
• 期刊: The Journal of cell biology
• 作者: Hisata S;Sakisaka T;Baba T;Yamada T;Aoki K;Matsuda M;Takai Y
• 通讯作者: Takai Y

Mutation of Dock5, a member of the guanine exchange factor Dock180 superfamily, in the rupture of lens cataract mouse

鸟嘌呤交换因子 Dock180 超家族成员 Dock5 突变导致白内障小鼠晶状体破裂

• 发表时间: 2008
• 期刊: Exp. Eye Res 86
• 作者: Omi;N.;Kiyokawa;E.;et. al.
• 通讯作者: et. al.

Spatial Regulation of Phosphoinositide Turnover in Migrating MDCK Cells : Quantification by FRET imaging

迁移 MDCK 细胞中磷酸肌醇周转的空间调节：FRET 成像定量

• 发表时间: 2008
• 作者: T. Nishioka;K. Aoki;K. Hikake;H. Yoshizaki;E. Kiyokawa;M. Matsuda;西岡照子;西岡照子;Teruko Nishioka
• 通讯作者: Teruko Nishioka

The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf.

氨基末端 B-Raf 特异性区域介导 Raf 的钙依赖性同二聚化和异二聚化。

• 发表时间: 2006
• 期刊: EMBO J 25・15
• 作者: Terai K.;Matsuda M.
• 通讯作者: Matsuda M.

The Scaffold Protein Shoc2/SUR-8 Accelerates the Interaction of Ras and Raf

• DOI: 10.1074/jbc.m109.053975
• 发表时间: 2010-03-05
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Matsunaga-Udagawa, Rie;Fujita, Yoshihisa;Matsuda, Michiyuki
• 通讯作者: Matsuda, Michiyuki