Isolation and characterization of cancer-related genes in mouse models

小鼠模型中癌症相关基因的分离和表征

• 批准号: 17013033
• 负责人: KOMINAMI Ryo
• 金额: $ 31.81万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17013033/
• 关键词: 研究分担者; Bcl11b遺伝子; がん抑制遺伝子; 細胞増殖; アポトーシス; 機能解析; Bcl11b; Wnt/β-cateninシグナル; 大腸がん; TOP/FOPflash; 亜鉛フィンガードメイン; リンパ腫; Bclllb遺伝子; 胸腺リンパ腫; Chk1

Analysis of radiation-induced thymic lymphomas and atrophic thymuses revealed that Bcl11b functions as a suppressor at an early stage of the lymphoma development. Bcl11b transcription factor downregulates Chk1 check point kinase and its targets include cell cycle inhibitors such as p27 kip1 and p57 kip2 and also β-catenin. Deregulation of these proteins in Bcl11b heterozygous mice contributes to development of lymphomas and colon cancers.

辐射诱导的胸腺淋巴瘤和萎缩的胸腺的分析表明，Bcl 11 b功能作为一个抑制剂在淋巴瘤发展的早期阶段。Bcl 11b转录因子下调Chk 1检查点激酶，其靶点包括细胞周期抑制剂如p27 kip 1和p57 kip 2以及β-连环蛋白。在Bcl 11b杂合子小鼠中这些蛋白的失调有助于淋巴瘤和结肠癌的发展。

项目成果

An Essential Developmental Checkpoint for Production of the T Cell Lineage

• DOI: 10.1126/science.1188995
• 发表时间: 2010-07-02
• 期刊: SCIENCE
• 影响因子: 56.9
• 作者: Ikawa, Tomokatsu;Hirose, Satoshi;Kawamoto, Hiroshi
• 通讯作者: Kawamoto, Hiroshi

Bclllb heterozygosity promotes clonal expansion and differentiation arrest of thymocytes in y-irradiated mice.

Bclllb杂合性促进γ-照射小鼠中胸腺细胞的克隆扩增和分化停滞。

• 发表时间: 2010
• 期刊: Cancer Science 101
• 作者: Go R;Hirose S;Morita S;Yamamoto T;Katsuragi Y;Mishima Y;Kominami R.
• 通讯作者: Kominami R.

Effect of Bclllb genotypes and gamma-radiation on the development of mouse thymic lymphomas.

Bclllb 基因型和伽玛辐射对小鼠胸腺淋巴瘤发展的影响。

• 发表时间: 2008
• 期刊: Biochem Biophys Res Commun. 373
• 作者: Yoshikai Y;Sato T;Morita S;Kohara Y;Takagi R;Mishima Y;Kominami R.
• 通讯作者: Kominami R.

Mtf-1 lymphoma-susceptibility locus affects retention of large thymocytes with high ROS levels in mice after γ-irradiation.

Mtf-1淋巴瘤易感位点影响γ射线照射后小鼠体内高ROS水平的大胸腺细胞的保留。

• 发表时间: 2007
• 期刊: Biochemical and Biophysical Research Communications 354
• 作者: Kamimura K;Mishima Y;Obata M;Endo T;Aoyagi Y;Kominami R.;K. Kamimura;K. Kamimura;H. Ohi;K.Kamimura;K.Kamimura;H.Ohi;M.Maruyama
• 通讯作者: M.Maruyama

Expression of TCRab partly rescues developmental arrest and apoptosis of ab T cells in Bcl11b^<-/->mice^1

TCRab 的表达部分挽救了 Bcl11b^</-/-> 小鼠 ^1 中 ab T 细胞的发育停滞和凋亡

• 发表时间: 2006
• 期刊: The Journal of Immunology (発表予定)
• 作者: Kominami R;Niwa O.;R.Kominami;J.Inoue;Jun Inoue
• 通讯作者: Jun Inoue