Regulation of cell proliferation by receptor tyrosine kinase

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Point mutations and structural alterations of receptor tyrosine kinase genes cause cancer and developmental abnormalities. Mutations of the RET tyrosine kinase gene is responsible for the development of multiple endocrine neoplasia type 2 and Hirschsprung's disease. The mutations result in RET activation and inactivation by various mechanisms. In this study, we elucidated the roles of each downstream signaling of RET in cancer cell growth, invasion and metastasis using RET-expressing cancer cell lines and transgenic mice.