Lymphangiogenesis in cancer
Lymphangiogenesis in cancer
批准号:
17014047
负责人:
KUBO Hajime
金额:
$29.06万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009
中文摘要
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英文摘要
To find the way of the inhibition of metastasis is important for cancer therapy. We found 2 important mechanisms in metastasis; 1) the role of lymphagiogenesis, 2) the induction of cancer stem cells from non-cancer stem cells. Lymphangiogenesis promotes the metastasis. We succeeded the inhibition of metastasis by anti-lymphangiogenesis therapy in mouse model. However, we found that cancer stem cells don't have the potential of lymphangiogenesis. To inhibit the metastasis, it could be important to target the induction of cancer stem cells in the metastatic sites.
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リンパ管新生の分子機構とがんリンパ節転移
淋巴管生成与癌症淋巴结转移的分子机制
DOI:
--
发表时间:
2006
期刊:
影响因子:
--
作者:
[Kumasaka T, Seyama K Mitani K, Souma S Kashiwagi S, Hebisawa A, Sato T, Kubo H Gomi K, Shibuya K, Fukuchi Y, Suda K, 久保肇, 久保肇, 久保肇, 久保肇, 久保肇]
通讯作者:
久保肇
がんとリンパ管;そしてリンパ管関連分子とがんについて
癌症与淋巴管;淋巴管相关分子与癌症
DOI:
--
发表时间:
2005
期刊:
影响因子:
--
作者:
[河野朋哉, 久保肇, Chikage Suzuki, 久保肇, Mayumi Jijiwa, 久保肇]
通讯作者:
久保肇
DOI:
10.1093/intimm/dxm041
发表时间:
2007-06-01
期刊:
INTERNATIONAL IMMUNOLOGY
影响因子:
4.4
作者:
[Mori, Kazuya, Itoi, Manami, Amagai, Takashi]
通讯作者:
Amagai, Takashi
DOI:
10.1016/j.jss.2007.12.762
发表时间:
2008-11
期刊:
The Journal of surgical research
影响因子:
--
作者:
[Kae Okoshi;H. Kubo;S. Nagayama;C. Tabata;Y. Kadokawa;S. Hisamori;Y. Yonenaga;A. Fujimoto;A. Mori;H. Onodera;G. Watanabe;Y. Sakai]
通讯作者:
Kae Okoshi;H. Kubo;S. Nagayama;C. Tabata;Y. Kadokawa;S. Hisamori;Y. Yonenaga;A. Fujimoto;A. Mori;H. Onodera;G. Watanabe;Y. Sakai
DOI:
10.1097/01.pas.0000172192.25295.45
发表时间:
2005-10-01
期刊:
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
影响因子:
5.6
作者:
[Kumasaka, T, Seyama, K, Suda, K]
通讯作者:
Suda, K
共 34 条
Targeting therapy against cancer stem cells
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批准号:20390341
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$12.31万
-
财政年份:2008
-
负责人:KUBO Hajime
-
依托单位:
Anovel mechanism of tumor progression by the candidate tumor suppressor Proxl : RNA mutation in cancer
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批准号:18390345
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.28万
-
财政年份:2006
-
负责人:KUBO Hajime
-
依托单位:
Research for molecular mechanisms of lymphangiogenesis and lymph node metastasis
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批准号:16390378
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.15万
-
财政年份:2004
-
负责人:KUBO Hajime
-
依托单位:
海外基金