Role of cell adhesion signaling in the abnormal cell polarization of cancer cells

细胞粘附信号在癌细胞异常细胞极化中的作用

• 批准号: 17014055
• 负责人: TAKAI Yoshimi
• 金额: $ 263.42万
• 依托单位: Kobe University (2008-2009)Osaka University (2005-2007)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17014055/
• 关键词: 細胞増殖; 細胞運動; 細胞接着; 細胞極性; ネクチン; Necl; インテグリン; アファディン; 増殖因子受容体; Nec1-5; がん; Necl - 5; Necl-5

Cell adhesion molecules nectins and Necls were found to crucially regulate various cellular functions, including cell adhesion, polarization, morphology, movement, proliferation, differentiation, and survival, in cooperation with growth factor receptors and integrins. The molecular mechanisms underlying these functions were clearly elucidated. The dysfunctions of nectins and Necls were shown to be involved in the abnormal proliferation of cancer cells, leading to tumor invasion and metastasis. It was proposed that the normalization of the dysfunctions is the key to develop a new type of anti-cancer therapy.

细胞粘附分子连接素和Necls与生长因子受体和整合素合作，对细胞粘附、极化、形态、运动、增殖、分化和存活等多种细胞功能起着至关重要的调节作用。这些功能背后的分子机制被清楚地阐明。连接素和Necls的功能障碍参与了癌细胞的异常增殖，导致肿瘤的侵袭和转移。指出功能障碍的正常化是开发新型抗癌疗法的关键。

项目成果

APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle.

• DOI: 10.1523/jneurosci.1546-09.2009
• 发表时间: 2009-11-18
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Szodorai A;Kuan YH;Hunzelmann S;Engel U;Sakane A;Sasaki T;Takai Y;Kirsch J;Müller U;Beyreuther K;Brady S;Morfini G;Kins S
• 通讯作者: Kins S

Involvement of integrin-induced activation of protein kinase C in the formation of adherens junctions

• DOI: 10.1111/j.1365-2443.2007.01083.x
• 发表时间: 2007-05-01
• 期刊: GENES TO CELLS
• 影响因子: 2.1
• 作者: Ozaki, Misa;Ogita, Hisakazu;Takai, Yoshimi
• 通讯作者: Takai, Yoshimi

Rab3 GTPase-activating protein regulates synaptic transmission and plasticity through the inactivation of Rab3

• DOI: 10.1073/pnas.0600304103
• 发表时间: 2006-06-27
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Sakane, Ayuko;Manabe, Shinji;Sasaki, Takuya
• 通讯作者: Sasaki, Takuya

Activation of Rac by cadherin through the c-Src-Rap1-phosphatidylinositol 3-kinase-Vav2 pathway

• DOI: 10.1038/sj.onc.1209010
• 发表时间: 2006-01-01
• 期刊: ONCOGENE
• 影响因子: 8
• 作者: Fukuyama, T;Ogita, H;Takai, Y
• 通讯作者: Takai, Y

Roles of Necl-5/Poliovirus receptor and ROCK in the regulation of transformation of integrin αv(ss)3-based focal complexes into focal adhesions.

Necl-5/脊髓灰质炎病毒受体和 ROCK 在调节基于整合素 αv(ss)3 的局灶复合物转化为粘着斑中的作用。

• 发表时间: 2008
• 期刊: J Biol Chem 283
• 作者: Nagamatsu Y;Rikitake Y;Takahashi M;Deki Y;Ikeda W;Hirata K;Takai Y.
• 通讯作者: Takai Y.