Role of cell adhesion signaling in the abnormal cell polarization of cancer cells

细胞黏附分子Necins和Necl与生长因子受体和整合素协同作用，对细胞黏附、极化、形态、运动、增殖、分化和存活等多种细胞功能起着重要的调节作用。这些功能背后的分子机制被清楚地阐明。Necl和Necins的功能失调参与了肿瘤细胞的异常增殖，导致肿瘤的侵袭和转移。提出功能正常化是开发新型抗癌治疗的关键。

Cell adhesion molecules nectins and Necls were found to crucially regulate various cellular functions, including cell adhesion, polarization, morphology, movement, proliferation, differentiation, and survival, in cooperation with growth factor receptors and integrins. The molecular mechanisms underlying these functions were clearly elucidated. The dysfunctions of nectins and Necls were shown to be involved in the abnormal proliferation of cancer cells, leading to tumor invasion and metastasis. It was proposed that the normalization of the dysfunctions is the key to develop a new type of anti-cancer therapy.