Disorganization of cell and tissue systems in cancer

癌症中细胞和组织系统的紊乱

• 批准号: 16060101
• 负责人: TAKAI Yoshimi
• 金额: $ 13.25万
• 依托单位: Kobe University (2008-2009)Osaka University (2004-2007)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16060101/
• 关键词: がん; 細胞運動; 細胞増殖; 細胞接着; 組織; 増殖; 細胞死; 細胞極性; 分化; 浸潤; 転移; 浸潤・転移; 接着; 細胞外マトリックス

A number of previous studies revealed the properties of cancer cells at the levels of genes and cells, contributing to the elucidation of the mechanisms by which cancer is a life-threatening disease. Based on accumulating lines of evidence concerning cancer cells, it was systematically investigated in this project how "the initiation and progression of cancer" are induced in terms of the disorganization of cell and tissue systems in cancer. It was found that abnormalities of cell movement, proliferation, and adhesion in cancer cells play important roles in this disorganization.

先前的许多研究揭示了癌细胞在基因和细胞水平上的特性，这有助于阐明癌症是一种威胁生命的疾病的机制。基于累积有关癌细胞的证据线，在该项目中有系统地研究了“癌症的启动和进展”是如何根据癌症细胞和组织系统的混乱而诱导的。发现癌细胞中细胞运动，增殖和粘附的异常在这种混乱中起着重要作用。

项目成果

Radixin deficiency causes deafness associated with progressive degeneration of cochlear stereocilia.

根黄素缺乏会导致与耳蜗静纤毛进行性退化相关的耳聋。

• DOI: 10.1083/jcb.200402007
• 发表时间: 2004-08-16
• 期刊: The Journal of cell biology
• 作者: Kitajiri S;Fukumoto K;Hata M;Sasaki H;Katsuno T;Nakagawa T;Ito J;Tsukita S;Tsukita S
• 通讯作者: Tsukita S

The Sticky Synapse : Cell Adhesion Molecules and Their Role in Synapse Formation and Maintenance

粘性突触：细胞粘附分子及其在突触形成和维持中的作用

• 发表时间: 2009
• 作者: Togashi;H.
• 通讯作者: H.

Activation of Cdc42 by trans interactions of the cell adhesion molecules nectins through c-Src and Cdc42-GEF FRG.

• DOI: 10.1083/jcb.200401093
• 发表时间: 2004-08-02
• 期刊: The Journal of cell biology
• 作者: Fukuhara T;Shimizu K;Kawakatsu T;Fukuyama T;Minami Y;Honda T;Hoshino T;Yamada T;Ogita H;Okada M;Takai Y
• 通讯作者: Takai Y

aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6.

aPKClambda/iota 通过白细胞介素 6 的转录激活以自分泌方式促进前列腺癌细胞的生长。

• 发表时间: 2009
• 期刊: Proc Natl Acad Sci U S A 106(38)
• 作者: Ishiguro H;Akimoto K;Nagashima Y;Kojima Y;Sasaki T;Ishiguro-Imagawa Y;Nakaigawa N;Ohno S;Kubota Y;Uemura H
• 通讯作者: Uemura H

Defective cell polarity in kidney podocytes causes severe glomerular disease

肾足细胞的细胞极性缺陷导致严重的肾小球疾病

• 发表时间: 2007
• 作者: Hirose T;Satoh D;Kuriharawa I;Noda T;Ohno S
• 通讯作者: Ohno S