Development of individualized diagnosis for cancer of digestive organ

消化器官肿瘤个体化诊断进展

• 批准号: 17015042
• 负责人: SAKAMOTO Michiie
• 金额: $ 42.69万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17015042/
• 关键词: 多段階発がん; 早期肝細胞がん; 浸潤性膵管がん; 神経浸潤; 移植モデル; 遺伝子発現プロファイル; プロテオーム; 浸潤; synuclein-Y; Schwann細胞; 予後因子; 悪性度; CD74

We found that cyclase-associated protein 2 (CAP2) is up-regulated in early HCC and is further up-regulated in progressed HCC. Another homologue CAP1 was overexpressed in pancreatic cancer and was involved in cancer cell motility and poor prognosis. We established a novel perineural invasion model and distinguished high- and low- perineural invasion group in pancreatic cancer. Gene expression analysis revealed CD74 as a possible molecule involved in perineural invasion. Proteomic analysis revealed synuclein-γ is closely involved in perineural invasion and distant metastasis and is a prognostic factor in pancreatic cancer.

我们发现环化酶相关蛋白2 （CAP2）在早期HCC中上调，在进展期HCC中进一步上调。另一个同源基因CAP1在胰腺癌中过表达，参与了癌细胞运动和不良预后。我们建立了一种新的胰腺周围神经浸润模型，并区分了高浸润组和低浸润组。基因表达分析显示CD74可能参与了神经周围浸润。蛋白质组学分析显示突触核蛋白-γ密切参与神经周围侵袭和远处转移，是胰腺癌的预后因素。

项目成果

Domain-specific function of ShcC docking protein in neuroblastoma cells

• DOI: 10.1038/sj.onc.1208523
• 发表时间: 2005-04-28
• 期刊: ONCOGENE
• 影响因子: 8
• 作者: Miyake, I;Hakomori, Y;Sakai, R
• 通讯作者: Sakai, R

Specific expression of hepatocyte nuclear factor-1β in the ovarian clear cell adenocarcinoma and its application to cytological diagnosis

• DOI: 10.1111/j.1349-7006.2007.00398.x
• 发表时间: 2007-03-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Higashiguchi, Atsushi;Yamada, Taketo;Sakamoto, Michiie
• 通讯作者: Sakamoto, Michiie

Construction of human monoclonal single-chain Fvantibodies against small-cell lung cancer by phagedisplay libraries derived from cell-immunized SCID mice engrafted with human peripheral blood lymphocytes.

通过源自植入人外周血淋巴细胞的细胞免疫 SCID 小鼠的噬菌体展示文库构建抗小细胞肺癌的人单克隆单链 Fvantibodies。

• 发表时间: 2009
• 期刊: Proteomics Clin Appl 3
• 作者: Douguchi J;Hashiguchi A;Sakamoto M.
• 通讯作者: Sakamoto M.

Gene therapy of liver timors with human liver-specific nanoparticles.

使用人类肝脏特异性纳米粒子对肝肿瘤进行基因治疗。

• 发表时间: 2007
• 期刊: Cancer Gene Therapy 14
• 作者: Iwasaki Y; Ueda M; Yamada T; Kondo A; Seno M; Tanizawa K; Kuroda S; Sakamoto M. Kitaiima M
• 通讯作者: Sakamoto M. Kitaiima M

CT Evalution of the Progression of Hypoattenuating Nodular Lesions in Virus-Related Chronic liver Disease

病毒相关慢性肝病低密度结节性病变进展的 CT 评估

• 发表时间: 2006
• 期刊: AJR 187
• 作者: Takaysu K;Muramatsu Y;Mizuguchi Y;Okusaka T;Shimada K;Tkayama T;Sakamoto M
• 通讯作者: Sakamoto M