课题基金 / 基金详情

Development of individualized diagnosis for cancer of digestive organ

Development of individualized diagnosis for cancer of digestive organ
消化器官肿瘤个体化诊断进展
批准号：
17015042
负责人：
SAKAMOTO Michiie
金额：
$42.69万
依托单位：
Keio University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas
财政年份：
2005
资助国家：
日本
项目状态：
已结题
起止时间：
2005 至 2009
来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17015042/
关键词：
多段階発がん早期肝細胞がん浸潤性膵管がん神経浸潤移植モデル遺伝子発現プロファイルプロテオーム浸潤synuclein-YSchwann細胞予後因子悪性度CD74

项目摘要

项目成果

SAKAMOTO Michiie的其他基金

相关文献

中文摘要
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英文摘要
We found that cyclase-associated protein 2 (CAP2) is up-regulated in early HCC and is further up-regulated in progressed HCC. Another homologue CAP1 was overexpressed in pancreatic cancer and was involved in cancer cell motility and poor prognosis. We established a novel perineural invasion model and distinguished high- and low- perineural invasion group in pancreatic cancer. Gene expression analysis revealed CD74 as a possible molecule involved in perineural invasion. Proteomic analysis revealed synuclein-γ is closely involved in perineural invasion and distant metastasis and is a prognostic factor in pancreatic cancer.
期刊论文(47)
专著(0)
科研奖励(0)
会议论文
Domain-specific function of ShcC docking protein in neuroblastoma cells
DOI： 10.1038/sj.onc.1208523
发表时间： 2005-04-28
期刊： ONCOGENE
影响因子： 8
作者： [Miyake, I, Hakomori, Y, Sakai, R]
通讯作者： Sakai, R
Specific expression of hepatocyte nuclear factor-1β in the ovarian clear cell adenocarcinoma and its application to cytological diagnosis
DOI： 10.1111/j.1349-7006.2007.00398.x
发表时间： 2007-03-01
期刊： CANCER SCIENCE
影响因子： 5.7
作者： [Higashiguchi, Atsushi, Yamada, Taketo, Sakamoto, Michiie]
通讯作者： Sakamoto, Michiie
Gene therapy of liver timors with human liver-specific nanoparticles.
使用人类肝脏特异性纳米粒子对肝肿瘤进行基因治疗。
DOI： --
发表时间： 2007
期刊： Cancer Gene Therapy 14
影响因子： --
作者： [Iwasaki Y, Ueda M, Yamada T, Kondo A, Seno M, Tanizawa K, Kuroda S, Sakamoto M. Kitaiima M]
通讯作者： Sakamoto M. Kitaiima M
Construction of human monoclonal single-chain Fvantibodies against small-cell lung cancer by phagedisplay libraries derived from cell-immunized SCID mice engrafted with human peripheral blood lymphocytes.
通过源自植入人外周血淋巴细胞的细胞免疫 SCID 小鼠的噬菌体展示文库构建抗小细胞肺癌的人单克隆单链 Fvantibodies。
DOI： --
发表时间： 2009
期刊： Proteomics Clin Appl 3
影响因子： --
作者： [Douguchi J, Hashiguchi A, Sakamoto M.]
通讯作者： Sakamoto M.
共 32 条
    Establishing the molecular pathology-based subclassification of hepatocellular carcinoma.
    • 批准号：
      26293081
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $10.23万
    • 财政年份：
      2014
    • 负责人：
      SAKAMOTO Michiie
    • 依托单位：
      Keio University
    Expression and functional analyses of G protein-coupled receptor GPR49/LGR5 in human tissues and diseases
    • 批准号：
      21390108
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $11.81万
    • 财政年份：
      2009
    • 负责人：
      SAKAMOTO Michiie
    • 依托单位：
      Keio University
    Molecular mechanisms of progression and metastasis of hepatocellular carcinoma and their application on diagnosis and therapy.
    • 批准号：
      15390118
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $9.15万
    • 财政年份：
      2003
    • 负责人：
      SAKAMOTO Michiie
    • 依托单位：
      Keio University
    Molecular mechanisms of intrahepatic metastasis of hepatocellular carcinoma and application for diagnosis and treatment
    • 批准号：
      12470049
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $3.65万
    • 财政年份：
      2000
    • 负责人：
      SAKAMOTO Michiie
    • 依托单位：
      NATIONAL CANCER CENTER