Analysis of resistance mechanism of cell death in chemotherapy and monoclonal antibody therapy
Analysis of resistance mechanism of cell death in chemotherapy and monoclonal antibody therapy
批准号:
17016077
负责人:
HATAKE Kitohiko
金额:
$29.57万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2010
中文摘要
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英文摘要
I studied basic research in drug resistance mechanism as well as clinical samples analysis. Imatinib resistance, partly is explained by ABL mutation and autophagy pathway will be a next target. Rituximab resistance in CD20+ lymphoma is explained partly by CD20 mutation. I established bortezomib-resistant myeloma cell line.We also established the assay system for ADCC and CDC.
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ADCCアッセイシステムの確立とADCC抵抗性因子の探索
ADCC检测体系的建立及ADCC耐药因子的寻找
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[三嶋雄二, ら]
通讯作者:
ら
Modified irinotecan plus bolus 5-fluorouracil/L-leucovorin for metastatic colorectal cancer at a single institution in Japan.
日本一家机构使用改良伊立替康加推注 5-氟尿嘧啶/L-亚叶酸治疗转移性结直肠癌。
DOI:
--
发表时间:
2008
期刊:
J Gastroenterol. 43(11)
影响因子:
--
作者:
[Suenaga M, et al]
通讯作者:
et al
Bone marrow-derived CXCR4+cells mobilized by macrophage colony-stimulating factor participate in the reduction of infarct area and improve ment of cardiac remodeling after myocardial infarction in mice.
巨噬细胞集落刺激因子动员的骨髓源性CXCR4细胞参与小鼠心肌梗塞后梗塞面积的缩小和心脏重塑的改善。
DOI:
--
发表时间:
2007
期刊:
Am J Pathol. 171
影响因子:
--
作者:
[Morimoto H, et. al.]
通讯作者:
et. al.
リツキシマブ既治療再発・難治B・NHLに対するInotuzumab Ozogamic in(CMC・544)の国内第I相試験
Inotuzumab Ozogamic 治疗利妥昔单抗治疗复发/难治性 B/NHL 的国内 I 期研究(CMC·544)
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Fukazawa H, Ikeda Y, Fukuyama M, Suzuki T, Hori H, Okuda T, Uehara Y, 畠清彦 他]
通讯作者:
畠清彦 他
DOI:
10.1111/j.1349-7006.2007.00571.x
发表时间:
2007-10-01
期刊:
CANCER SCIENCE
影响因子:
5.7
作者:
[Takahashi, Shunji, Aiba, Keisuke, Sugimoto, Yoshikazu]
通讯作者:
Sugimoto, Yoshikazu
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海外基金