System analysis of stability and plasticity of signal transduction

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We analyzed the stability and plasticity of signaling transduction cascades. We have especially targeted synaptic plasticity. We developed a computational model of spike-timing dependent plasticity (STDP) in the cerebral cortex, and we found that a novel allosteic kinetics of NMDA receptors is required for STDP. The tectal neurons in the Xenopus tadpole can respond to moving visual stimuli in one preferred direction than in any other direction. Acquirement of direction selectivity has been shown to be mediated through the modification of synaptic connectivity by STDP. We proposed a mechanism for the acquirement of direction selectivity with computational models of STDP and a retino-tectal circuit.