Genome-wide study on pathogenesis of bacteria causing nosocomial infection

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We employed Staphylococcus aureus, Serratia marcescens, Pseudomonas aeruginosa as target agent causing nosocomial infection. For S. aureus, we delineated gene sets present in S. aureus causing certain diseases and analyzed candidate genes to detect or foresee specific virulence of S. aureus. For S. marcescens, we screened for virulence-related genes by animal experiment and investigated for factors (genes) involved in human serum resistance. For P. aeruginosa, we investigated for factors (genes) involved in human serum resistance. We also analyzed characteristics and antimicrobial resistance mechanism of MDRP clones.