Deciphering mechanisms of synaptic remodeling at the morphological and functional levels

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Through this program, we identified several new CREB-regulatory kinases. Furthermore, we showed that the immediate early gene Arc is a bona fide CREB target gene, and elucidated the transcriptional mechanisms implicated in activity-dependent Arc gene activation. Additionally, we characterized the essential roles of CaMKI isoforms in the growth of dendrites and axons during the perinatal development of neuronal circuits. Finally, novel modes of regulation of PSD and presynaptic active zone scaffolding proteins (such as PSD-95, RIM1 and Shank) were investigated, with emphasis on their link with actin cytoskeletal remodeling. In parallel, we developed new protocols to visualize and manipulate synapse formation and morphological remodeling of neurons.