Activity-dependent mechanisms regulating dendriticmorphology and function

基于经验的信息处理和存储的分子机制仍然是难以捉摸的。在这里，在这个研究项目中，我们发现了新的分子见解：(1)CaMKK-CaMK级联在神经突形态发生中的作用，(2)接收突触活动后触发新基因表达的信号级联，以及(3)一种新的反向突触标记机制，该机制介导活动依赖基因表达的特定形式的突触调节。这些发现为在神经回路中转换和存储先前经验信息的机制提供了新的思路。

Molecular mechanisms underlying experience-dependent information processing and storage have remained elusive. Here, in this research program, we have uncovered novel molecular insights on (1)the role of CaMKK-CaMK cascade in neurite morphogenesis, (2) the signaling cascade that triggers new gene expression upon receipt of synaptic activity, and (3)a new inverse synaptic tagging mechanism that mediates specific forms of synaptic modulation upon activity-dependent gene expression. These findings shed new lights on the machinery that transforms and stores information about previous experience within the neural circuits.