Development of Advanced Molecular Transformations of Functional Carbon Molecules using Fine Acid-Base Catalysts

对于自然资源稀缺的日本来说，为了保持在医药和化工领域的国际优势，开发优良的合成有机反应制备重要材料是当务之急。在这一优先领域，我们高效地利用容易获得的碳资源，在真正有效的分子转化的基础上寻求新的碳-碳键形成反应。也就是说，不对称相转移化学被认为是过程合成有机化学中一种理想的方法，通过使用手性联萘修饰的季铵盐来开发新的、高效的不对称碳-碳键形成反应，从而开拓了这一领域。手性双功能有机催化剂和手性二元酸催化剂的合理设计也为开发几种新的不对称方法奠定了基础。

The development of excellent synthetic organic reactions to prepare important materials is urgent to Japan, where natural resources are scarce, as a scientific and technological country in order to keep the international superiority in the field of pharmaceutical and chemical industries. In this priority area, we utilize the readily accessible carbon resources efficiently, and pursuit new carbon-carbon bond-forming reactions based on the truly efficient molecular transformations. Namely, the field of asymmetric phase transfer chemistry, which is regarded as a desirable approach in process synthetic organic chemistry, has been exploited by using chiral binaphthyl-modified quaternary ammonium salts for the development of new, efficient asymmetric carbon-carbon bond-forming reactions. A rational design of chiral bifunctional organocatalysts and chiral dicarboxylic acid catalysts have been also realized for developing several new asymmetric methodologies.