Development of Advanced Molecular Transformations of Functional Carbon Molecules using Fine Acid-Base Catalysts

作为科技大国的日本，为了保持在医药和化学工业领域的国际优势，开发优良的有机合成反应来制备重要材料是当务之急。在这一优先领域，我们有效地利用容易获得的碳资源，并在真正有效的分子转化的基础上追求新的碳-碳键形成反应。也就是说，不对称相转移化学领域，这被认为是一个理想的方法，在有机化学合成过程中，已被利用手性联萘基改性的季铵盐的开发新的，有效的不对称碳-碳键形成反应。手性双功能有机催化剂和手性二元羧酸催化剂的合理设计也为开发新的不对称方法学奠定了基础。

The development of excellent synthetic organic reactions to prepare important materials is urgent to Japan, where natural resources are scarce, as a scientific and technological country in order to keep the international superiority in the field of pharmaceutical and chemical industries. In this priority area, we utilize the readily accessible carbon resources efficiently, and pursuit new carbon-carbon bond-forming reactions based on the truly efficient molecular transformations. Namely, the field of asymmetric phase transfer chemistry, which is regarded as a desirable approach in process synthetic organic chemistry, has been exploited by using chiral binaphthyl-modified quaternary ammonium salts for the development of new, efficient asymmetric carbon-carbon bond-forming reactions. A rational design of chiral bifunctional organocatalysts and chiral dicarboxylic acid catalysts have been also realized for developing several new asymmetric methodologies.