Interactions of transportsome and cytoskeleton

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We have identified SGIP1・ and its homologous molecules, FCHO1 and FCHO2, as novel microtubule-binding proteins. They bound not only to microtubules but also to membrane phospholipids and deformed membranes to tubules. SGIP1・ and FCHO2 were involved in clathrin-dependent endocytosis. FCHO2 regulated the ubiquitination and endocytosis of epithelial sodium channel (ENaC). In addition, FCHO2, which was also localized in centrosomes, regulated the organization of microtubules.