Molecular mechanism of brain layer formation regulated by Reelin

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Reelin is essential for brain layer formation, but its exact function and underlying mechanism are nor well understood. We found that the C-terminal region of Reelin plays important roles in the interaction between this protein and neuronal cell membrane. We identified the protease in charge of specific proteolysis of Reelin. We also investigated when and where Reelin is received in the developing brain and found that Reelin acts on pre/early migratory neurons,