Destabilisation of genome by the failure in the regulatory system of chromosome DNA replication which is controlled by cell cycle regulator, CDK

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Cancer is a mass of cells that has lost a normal cell cycle control. In human cancer cells, i) abnormality in cell cycle regulatory pathway and ii) destabilization of genome are observed as their hallmarks. Cyclin-dependent kinases, CDKs, not only regulate the progression of cell cycle, but also play a central role in limiting chromosome DNA replication to once per cell cycle. This research reveals that CDK regulates multiple factors for the initiation of DNA replication and having the multiple regulatory mechanisms is important for the stable genome maintenance.