Gene analysis of craniosynostosis
Gene analysis of craniosynostosis
批准号:
19791317
负责人:
TANAKA Seiji
金额:
$2.03万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
頭蓋骨早期癒合症症候群のなかでも頻度が高く、四肢の異常も生じるApert症候群の遺伝子治療の検討を行った。遺伝子変異によって生じる異常タンパクに対する抗体の作製を行った。この抗体の中和活性を評価し、中和活性の認められた抗体を用いてApert症候群モデルマウスに対する治療効果を評価していく予定である。本研究では抗体の中和活性を評価する実験系の作製を行った。
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会议论文
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