Roles of actin cytoskeletal regulation system in tumor cell migrationand invasion

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We investigated the roles of actin cytoskeletal regulation in tumor cell migration and invasion and obtained the results, as follows : Cofilin and its regulatory enzymes, LIM-kinase and Slingshot, play critical roles in the invadopodium formation. LIM-kinase is critical for the mesenchymal-to-amoeboid cell morphological transition of tunor cells in 3D matrices. Protein kinase D1 regulates actin reorganization through Slingshot inactivation. We also developed inhibitors for LIM-kinase and found that these inhibitors suppressed tumor cell invasion.