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Molecular mechanisms of mitotic spindle organization and positioning

Molecular mechanisms of mitotic spindle organization and positioning
有丝分裂纺锤体组织和定位的分子机制
批准号:
21370086
负责人:
MIZUNO Kensaku
金额:
$12.06万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
We investigated the mechanisms of mitotic spindle organization and positioning and obtained the following results. 1)Plk1 binds to and phosphorylates cofilin-phosphatase Slingshot during mitosis. 2)NDR kinase and its upsteam regulators, MST and Furry, are crucial for bipolar spindle organization and chromosome alignment in metaphase. 3)Furry is involved in the maintenance of spindle bipolarity by promoting Aurora A-mediated Plk1 activation on spindle poles.
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MST2- and Furry-mediated activation of NDR1 is critical for precise alignment of mitotic chromosomes
MST2 和 Furry 介导的 NDR1 激活对于有丝分裂染色体的精确对齐至关重要
DOI: --
发表时间: 2009
期刊: Curr.Biol. 19
影响因子: --
作者: [Chiba, S., et al.]
通讯作者: et al.
NDRキナーゼの活性制御機構と染色体整列における機能
NDR激酶活性控制机制及其在染色体排列中的作用
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [水野健作, 千葉秀平, 池田真教, 大橋一正]
通讯作者: 大橋一正
Furry is involved in bipolar spindle form ation through Plk1 activation
Furry 通过 Plk1 激活参与双极纺锤体形成
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Masanori Ikeda, Shuhei Chiba, Kazumasa Ohashi, Kensaku Mizuno]
通讯作者: Kensaku Mizuno
DOI: 10.1074/jbc.m111.259135
发表时间: 2011-10-21
期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子: 4.8
作者: [Ohashi, Kazumasa, Fujiwara, Sachiko, Mizuno, Kensaku]
通讯作者: Mizuno, Kensaku
40
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    • 批准号:
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