Regulation of transformation and cell growth by molecules controlling cell death

通过控制细胞死亡的分子调节转化和细胞生长

• 批准号: 20013020
• 负责人: YONEHARA Shin
• 金额: $ 10.24万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20013020/
• 关键词: 細胞死; 遺伝子; 癌; 細胞・組織; シグナル伝達

We show that tetraploid cells induced by impaired mitotic chromosomal condensation are eliminated by a novel type of cell death different from caspase-dependent apoptosis. The cell death was executed by the downregulation of eukaryotic translation elongation factor 1 alpha 1 (eEF1A1), a typical housekeeping gene products. The downregulation of eEF1A1 expression was shown to be induced by both destabilization of its mRNA and its translational inhibition.

我们发现，有丝分裂染色体浓缩受损诱导的四倍体细胞被一种不同于半胱天冬酶依赖性细胞凋亡的新型细胞死亡所消除。细胞死亡是通过下调真核翻译延伸因子1 α 1（eEF 1A1）（一种典型的管家基因产物）来执行的。eEF1A1表达的下调被证明是由其mRNA的不稳定和其翻译抑制引起的。

项目成果

Novel caspase-independent cell death by downregulation of eEF1A1/EF-1αexpression in tetraploids with chromosomal aberrations

染色体畸变四倍体中 eEF1A1/EF-1α 表达下调导致新型 caspase 依赖性细胞死亡

• 发表时间: 2008
• 作者: 長谷川菜摘;笠井愛友子;森近舞;田路紗和子;井上佳奈;堀江修;浦浜憲永;伊藤光宏;Shin Yonehara
• 通讯作者: Shin Yonehara

RPA-like Mammalian Ctcl-Stnl-Tenl Complex Binds to Single-Stranded DNA and Protects Telomeres Independently of the Potl Pathway

RPA 样哺乳动物 Ctcl-Stnl-Tenl 复合物与单链 DNA 结合并独立于 Potl 途径保护端粒

• 发表时间: 2009
• 期刊: Mol Cell 36
• 作者: Miyake Y;Nakamura M;Nabetani A;Shimamura S;Tamura M;Yonehara S;Saito M;Isikawa F
• 通讯作者: Isikawa F

Novel types of cell death identified in 1989 and 2008

1989 年和 2008 年发现的新型细胞死亡

• 发表时间: 2008
• 作者: 南智也;井上佳奈;住友明子;田路紗和子;辻友恵;堀江修;浦浜憲永;伊藤光宏;Shin Yonehara
• 通讯作者: Shin Yonehara

RPA-like Mammalian Ctc1-Stn1-Ten1 Complex Binds to Single-Stranded DNA and Protects Telomeres Independently of the Pot1 Pathway

• DOI: 10.1016/j.molcel.2009.08.009
• 发表时间: 2009-10-23
• 期刊: MOLECULAR CELL
• 影响因子: 16
• 作者: Miyake, Yasuyuki;Nakamura, Mirai;Ishikawa, Fuyuki
• 通讯作者: Ishikawa, Fuyuki

Novel cell death by downregulation of eEF1A1 expression in tetraploids

• DOI: 10.1038/cdd.2008.136
• 发表时间: 2009-01-01
• 期刊: CELL DEATH AND DIFFERENTIATION
• 影响因子: 12.4
• 作者: Kobayashi, Y.;Yonehara, S.
• 通讯作者: Yonehara, S.