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Development of Nano-Sized Supports for Polymerization

纳米级聚合载体的开发

基本信息

批准号：
14078214
负责人：
CHUJO Yoshiki
金额：
$ 20.35万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2005
项目状态：
已结题

项目摘要

1. Effect of Iron (III) Hydroxide Sol as a Support for Oligomerization of L-Phenylalanine in Aqueous Solution An oligomerization of L-phenylalanine in aqueous solution was studied in the presence of iron (III) hydroxide sols.2. Effect of gold nanoparticles as a support for oligomerization of L-cysteine in aqueous solution: We studied a new system for the oligomerizaion of amino acids using gold nanoparticles as nano-sized supports. In this system, we used L-cysteine, which is water-soluble and would readily bind to the surface of gold nanoparticles via a thiolate linkage. After oligomerizaion, the gold nanoparticles were re-oxidized with iodine and dissolve in water again. The resulting products were simply isolated by filtration since oligomer is not soluble in water by cross-linking via disulfide bond.3. Polycondensation of Activated Valine Esters in the Presence of a Lewis Acid : We have succeeded in a novel polycondensation of activated amino acid esters in the presence of Lewis acids. When the polymerization of p-nitrophenyl L-valinate hydrobromide was carried out in DMF in the presence of yttrium(III) trifluoromethanesulfonate, a polymer, of which the number-average molecular weight was 3000, was obtained. On the contrary, in the absence of the Lewis acid, no polymer was obtained. These results suggest that the polycondensation of the amino acid ester proceeded by the Lewis acid.

1.氢氧化铁溶胶作为载体对L-苯丙氨酸水溶液齐聚反应的影响研究了在氢氧化铁溶胶存在下，L-苯丙氨酸在水溶液中的齐聚反应.金纳米粒子作为载体对L-半胱氨酸在水溶液中寡聚化的影响：我们研究了一种使用金纳米粒子作为纳米尺寸载体的氨基酸寡聚化的新体系。在这个系统中，我们使用了L-半胱氨酸，它是水溶性的，很容易通过硫醇键结合到金纳米粒子的表面。在低聚化之后，金纳米颗粒用碘再氧化并再次溶解在水中。所得产物通过过滤简单地分离，因为低聚物通过经由二硫键交联而不溶于水。在刘易斯酸存在下活化的缬氨酸酯的缩聚：我们已经成功地在刘易斯酸存在下活化的氨基酸酯的新型缩聚。当在DMF中在三氟甲磺酸钇（III）的存在下进行L-缬氨酸对硝基苯基酯氢溴酸盐的聚合时，获得数均分子量为3000的聚合物。相反，在不存在刘易斯酸的情况下，没有获得聚合物。这些结果表明，氨基酸酯的缩聚反应是由刘易斯酸进行的。