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チェルノブイリ周辺甲状腺がんの分子疫学調査

切尔诺贝利周边地区甲状腺癌的分子流行病学调查

基本信息

批准号：
15026212
负责人：
柴田義貞
金额：
$ 3.2万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas
财政年份：
2003
资助国家：
日本
起止时间：
2003 至无数据
项目状态：
已结题

项目摘要

国際機関との共同プロジェクトとして、小児甲状腺がんの症例対照研究および特定被曝集団の長期追跡調査を実施すると共に、国際甲状腺組織登録バンクの管理運営に継続参加し、チェルノブイリ周辺での手術標本を基に各種免疫組織学的解析および甲状腺がん関連遺伝子の解析を行い、主として以下の成果を得た。1.新らしいret/PTC遺伝子異常の再配列を発見した。2.c-abl非受容体型チロシンリン酸化酵素の甲状腺がん過剰発現を証明し、p53異常におけるc-abl過剰発現を分子標的とした新たな治療法の開発を行った。3.放射線誘発甲状腺がんの組織型特異性と遺伝子異常との関連では、BRAF遺伝子のV599E点突然変異が乳頭がん組織に高頻度で見られることを証明し、現在特異抗体の作成を行っている。同時にBRAF遺伝子異常のトランスジェニックマウスの作成に着手している。4.甲状腺がんの新しい細胞内情報伝達系の異常所見として、beta-cateninの局在異常とがん化機構への関与を明らかにし、さらにp300/CBP核内遺伝子異常やサイトカインの一つであるPTHrPとその受容体の発現異常などを報告した。5.放射線疫学調査の一貫として、2001年度の施行したベラルーシ共和国ゴメリ州における小児甲状腺がんの尿中ヨードの測定結果をカザフスタン共和国セミパラチンスク周辺と比較し、現在ではこれら旧ソ連地域にヨード不足がないことを確認した。6.さらに現地のヨウ素欠乏の広範囲な調査結果をまとめ、放射線ヨウ素による初期甲状腺障害の予防に果たす安定ヨウ素剤の服用効果を明らかにした。7.チェルノブイリ関連プロジェクトの総括を行い、現時点での学術共同研究の問題点と今後研究の方向性を提言し、国際的な単行本として出版した。

The International Organization of the thyroid has been involved in the study of cases of thyroid disease and small thyroid disease in accordance with the case study. It has been revealed that it has been specifically exposed that long-term follow-up of thyroid cancer has been conducted in a long-term manner, and that the international thyroid organization has been involved in the management and management of thyroid cancer. Thank you for the following achievements. 1. The new "ret/PTC" is often assigned to the list of "see". 2.c-abl non-receptive phenotypic acid enzyme acidification enzyme for thyroid screening has been shown to be sensitive, p53 has been used to detect c-abl, and a new method for the treatment of molecules has been developed. 3. Radioimmunoassay showed that the specific antibody of the thyroid gland was abnormal, the V599E point of the BRAF antibody was suddenly detected, the tissue of the breast tissue was detected, and now the specific antibody was used to form the antibody. At the same time, the BRAF children often make sure that they do not need to pay attention to each other. 4. New thyroid cell information reports are commonly seen in the thyroid gland, the beta-catenin bureau has been used in the chemical machinery of the p300/CBP, and the p300/CBP nuclear drug has been detected as soon as it is reported that the recipient is suffering from the disease. 5. The results of the measurement of urine samples in the Republic of China in 2001, the results of the measurement of urine samples in the Republic of China, the results of the measurement of urine samples in the Republic of China, the results of the measurement of urine samples in the Republic of China, the results of the measurement of urine samples in the Republic of China, the results of the measurement of urine samples in the Republic of China, the results of the measurement of urine samples in the Republic of China, the results show that the results of the measurement of urine samples in the Republic of China have not been verified. 6. There was a lack of hormone in the local area. The results showed that the initial thyroid damage caused by radiation and radiation should be treated with diazepam and diazepam. 7. We are interested in the publication of future research directions and international publications, including the joint research of the industry and the academic community on a timely basis.