Fibroblast dynamics to mitigate tissue damage (B06)

成纤维细胞动力学减轻组织损伤 (B06)

• 批准号: 505074941
• 金额: --
• 依托单位: Institut für Kardiovaskuläre Regeneration
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2022
• 资助国家: 德国
• 起止时间: 2021-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/505074941?language=en
• 关键词: Fibroblast; dynamics; mitigate; tissue; damage

The project will identify cytokines and growth factors signalling to and from cardiac fibroblasts (CFs) which influence the damage response of the stroma vascular compartment. We have identified a novel lineage of CFs residing in the adventitia and labelled by LepR-Cre. At baseline, this CF subset is rare, but expands to produce the majority of scar fibroblasts after myocardial infarction. We will test whether LepR-Cre+ CFs are tissue-resident fibroblast progenitors and explore the role of leptin signalling on their activation. In addition, we will conduct ex vivo studies assessing autocrine and paracrine (on endothelial and immune cells) effects of a set of cytokines expressed by (pre)proliferative CFs.

该项目将确定细胞因子和生长因子信号传导到心脏成纤维细胞（CF），影响基质血管室的损伤反应。我们已经确定了一个新的谱系的CF居住在外膜和标记的LepR-Cre。在基线时，这种CF亚群是罕见的，但在心肌梗死后扩大到产生大多数瘢痕成纤维细胞。我们将测试LepR-Cre+ CF是否是组织驻留的成纤维细胞祖细胞，并探索瘦素信号传导对其激活的作用。此外，我们将进行离体研究，评估自分泌和旁分泌（对内皮细胞和免疫细胞）的一组细胞因子（前）增殖CF表达的影响。