Magnetic Resonance without Magnetic Field

传统的高场液态核磁共振（NMR）是一种强大的方法，但实验需要在特定的环境中进行（在高度均匀的磁场内），这阻碍了它在许多应用中的应用。通过溶解-动态核极化（dDNP）[3-5]耦合零至超低场（ZULF）[1]和超极化[2]的磁共振[3-5]，可以在金属容器和具有高磁化率非均质性的多孔介质等具有挑战性的环境中对任意分子进行敏感的高分辨率磁共振。这需要一个结合这两种技术的可靠的实验装置。由于顺磁剂引起的弛豫，用dDNP增强零场核磁共振具有挑战性。我们认为，这一限制将因使用法国共同申请国最近介绍的超极化矩阵而解除。我们将使用超极化和ZULF NMR的组合来研究不饱和化合物的催化加氢，非均相酶促过程以及低聚和聚合过程。特别是，这将使均相和非均相催化过程的NMR比较。

Conventional high field liquid state nuclear magnetic resonance (NMR) is a powerful method but experiments need to be performed in a specific environment (inside a highly homogeneous magnetic field), which prevents its use in many applications. Coupling magnetic resonance at zero- to ultralow field (ZULF) [1] with hyperpolarization [2] by dissolution-dynamic nuclear polarization (dDNP) [3–5] allows for sensitive high resolution magnetic resonance with arbitrary molecules in challenging environments like metal containers and porous media with high magnetic susceptibility heterogeneities. This requires a robust experimental setup combining the two techniques. Boosting NMR at zero field with dDNP is challenging because of relaxation induced by paramagnetic agents. We believe that this limitation will be lifted by the use of hyperpolarizing matrices recently introduced by the French co-applicant. We will use the combination of hyperpolarization and ZULF NMR to investigate catalytic hydrogenation of unsaturated compounds, heterogeneous enzymatic processes and oligomerization and polymerization processes. In particular, this will enable the comparison of homogeneous vs. heterogeneous catalytic processes by NMR.