Protein Structure and Dynamics by Electron/Nuclear Paramagnetic Resonance

通过电子/核顺磁共振研究蛋白质结构和动力学

• 批准号: DP240100273
• 负责人: Prof Nicholas Cox
• 金额: $ 54.02万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240100273
• 关键词: Protein; Structure; Dynamics; Electron; Nuclear

This interdisciplinary project aims to establish new magnetic resonance methods for the analysis of protein structure and motion at low concentrations and in physiological conditions that are otherwise difficult or impossible to study. It brings together four different research groups with expertise in advanced biochemistry, modern magnetic spectroscopy and high-performance computing. The project expects to develop tools to study protein structure, protein-protein association and protein-ligand interactions of established drug-targets. Expected outcomes include new techniques that quickly inform how drugs work, providing significant benefits to many researchers studying biomolecules, and supporting Australia’s growing biotechnology sector.

该跨学科项目旨在建立新的磁共振方法，用于分析低浓度和生理条件下的蛋白质结构和运动，否则很难或不可能进行研究。它汇集了四个不同的研究小组，拥有先进生物化学，现代磁光谱学和高性能计算的专业知识。该项目预计将开发工具来研究蛋白质结构，蛋白质-蛋白质缔合和蛋白质-配体相互作用的既定药物靶点。预期成果包括快速告知药物如何工作的新技术，为许多研究生物分子的研究人员提供重大利益，并支持澳大利亚不断发展的生物技术部门。