Aerosol-assisted synthesis of spherical mesoporous CeO2 parTicles as smart nAnoCarriers for theranosTIC

气溶胶辅助合成球形介孔 CeO2 颗粒作为用于 theranosTIC 的智能纳米载体

• 批准号: 505888839
• 负责人: Professor Dr. Alfred Weber
• 金额: --
• 依托单位: Institut für Mechanische Verfahrenstechnik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/505888839?language=en
• 关键词: Aerosol; assisted; synthesis; spherical; mesoporous

Nowadays, we are faced with the issue that conventional drug delivery systems must be administered systematically in high doses and tend to cause severe side-effects because of the nonspecific uptake of drugs by healthy tissues/organs. In this work, an easily controllable aerosol-based approach is proposed to produce biocompatible, mesoporous cerium oxide particle with well-controlled internal morphology and shell porosity for controlling the drug loading and release properties. Moreover, in order to have a specific release we will chemically modify these particles with modified polysaccharides (elaboration of stimuli-responsive systems). The ultimate goal of our project is to propose a theranostic platform capable of assessing diseased cells and able to deliver therapeutic molecules in a controllable way.

目前，我们面临的问题是，传统的给药系统必须以系统的高剂量给药，并且由于健康组织/器官对药物的非特异性吸收而容易引起严重的副作用。在这项工作中，提出了一种易于控制的基于气溶胶的方法来生产具有生物相容性的介孔氧化铈颗粒，该颗粒具有良好的内部形态和外壳孔隙度，可以控制药物的装载和释放性能。此外，为了获得特定的释放，我们将用改性多糖对这些颗粒进行化学修饰（刺激反应系统的细化）。我们项目的最终目标是提出一个能够评估患病细胞的治疗平台，并能够以可控的方式提供治疗分子。