Molecular mechanisms for regression of matured synapses as a neuronal basis for Rett syndrome

成熟突触退化的分子机制作为雷特综合征的神经元基础

• 批准号: 16K19672
• 负责人: Narushima Madoka
• 金额: $ 2.5万
• 依托单位: National Institute for Physiological Sciences (2017)Tokyo Women's Medical University (2016)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16K19672/
• 关键词: シナプス; 発達; 維持; mGluR1; MeCP2; レット症候群; 代謝型グルタミン酸受容体; 外側膝状体; 退行; 脳・神経; 脳神経疾患; 神経科学; 生理学

项目成果

The metabotropic glutamate receptor subtype 1 mediates experience-dependent maintenance of mature synaptic connectivity in the dorsal lateral geniculate nucleus

代谢型谷氨酸受体亚型 1 介导背外侧膝状核中成熟突触连接的经验依赖性维持

• 发表时间: 2017
• 作者: Madoka Naruhsima;Motokazu Uchigashima;Yuki Yagasaki;Takeshi Harada;Yasuyuki Nagumo;Naofumi Uesaka;Kouichi Hashimoto;Atsu Aiba;Masahiko Watanabe;Mariko Miyata;Masanobu Kano;Madoka Narushima
• 通讯作者: Madoka Narushima

Comparison of the role of metabotropic glutamate receptor subtype 1 in developmental refinement of neuronal connectivity between the cerebellum and the sensory thalamus

代谢型谷氨酸受体亚型 1 在小脑和感觉丘脑之间神经元连接发育细化中的作用比较

• DOI: 10.1016/j.neures.2017.06.004
• 发表时间: 2018
• 期刊: Neuroscience Research
• 影响因子: 2.9
• 作者: 柿原聡美;宗宮仁美;大西諒司;今村優太;福光秀文;Madoka Narushima
• 通讯作者: Madoka Narushima

Cortical activity regulates refinement of afferent lemniscal synapses in the somatosensory thalamus.

皮质活动调节体感丘脑传入丘系突触的细化。

• 发表时间: 2016
• 作者: Madoka Narushima;Miyata Mariko
• 通讯作者: Miyata Mariko

Activation of the metabotropic glutamate receptor subtype 1 is necessary for visual experience-dependent maintenance of synaptic connectivity in the dorsal lateral geniculate nucleus.

代谢型谷氨酸受体亚型 1 的激活对于视觉体验依赖性维持背外侧膝状核突触连接是必要的。

• 发表时间: 2017
• 作者: Madoka Naruhsima;Motokazu Uchigashima;Yuki Yagasaki;Takeshi Harada;Yasuyuki Nagumo;Naofumi Uesaka;Kouichi Hashimoto;Atsu Aiba;Masahiko Watanabe;Mariko Miyata;Masanobu Kano;Madoka Narushima;鳴島 円
• 通讯作者: 鳴島 円

The Metabotropic Glutamate Receptor Subtype 1 Mediates Experience-Dependent Maintenance of Mature Synaptic Connectivity in the Visual Thalamus

• DOI: 10.1016/j.neuron.2016.07.035
• 发表时间: 2016-09-07
• 期刊: NEURON
• 影响因子: 16.2
• 作者: Narushima, Madoka;Uchigashima, Motokazu;Kano, Masanobu
• 通讯作者: Kano, Masanobu