Functional analyses and developments of new therapies targeting LSD1 in gastrointestinal cancers

胃肠道癌症中针对LSD1的功能分析和新疗法的开发

• 批准号: 16K19941
• 负责人: KOSUMI Keisuke
• 金额: $ 2.5万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16K19941/
• 关键词: がん代謝; 消化器癌; バイオマーカー; エピジェネティクス; がん免疫; LSD1; オートファジー; 腫瘍免疫; 腸内細菌; 予後予測マーカー; 炎症

项目成果

Prognostic and clinical impact of PIK3CA mutation in gastric cancer: pyrosequencing technology and literature review.

• DOI: 10.1186/s12885-016-2422-y
• 发表时间: 2016-07-07
• 期刊: BMC cancer
• 影响因子: 3.8
• 作者: Harada K;Baba Y;Shigaki H;Ishimoto T;Miyake K;Kosumi K;Tokunaga R;Izumi D;Ohuchi M;Nakamura K;Kiyozumi Y;Kurashige J;Iwatsuki M;Miyamoto Y;Sakamoto Y;Yoshida N;Watanabe M;Baba H
• 通讯作者: Baba H

Body mass index and risk of colorectal carcinoma subtypes classified by tumor differentiation status.

• DOI: 10.1007/s10654-017-0254-y
• 发表时间: 2017-05
• 期刊: European journal of epidemiology
• 影响因子: 13.6
• 作者: Hanyuda A;Cao Y;Hamada T;Nowak JA;Qian ZR;Masugi Y;da Silva A;Liu L;Kosumi K;Soong TR;Jhun I;Wu K;Zhang X;Song M;Meyerhardt JA;Chan AT;Fuchs CS;Giovannucci EL;Ogino S;Nishihara R
• 通讯作者: Nishihara R

Association of Dietary Patterns With Risk of Colorectal Cancer Subtypes Classified by Fusobacterium nucleatum in Tumor Tissue.

• DOI: 10.1001/jamaoncol.2016.6374
• 发表时间: 2017-07-01
• 期刊: JAMA oncology
• 影响因子: 28.4
• 作者: Mehta RS;Nishihara R;Cao Y;Song M;Mima K;Qian ZR;Nowak JA;Kosumi K;Hamada T;Masugi Y;Bullman S;Drew DA;Kostic AD;Fung TT;Garrett WS;Huttenhower C;Wu K;Meyerhardt JA;Zhang X;Willett WC;Giovannucci EL;Fuchs CS;Chan AT;Ogino S
• 通讯作者: Ogino S

Aspirin exerts high anti-cancer activity in PIK3CA-mutant colon cancer cells.

• DOI: 10.18632/oncotarget.20972
• 发表时间: 2017-10-20
• 期刊: Oncotarget
• 作者: Gu M;Nishihara R;Chen Y;Li W;Shi Y;Masugi Y;Hamada T;Kosumi K;Liu L;da Silva A;Nowak JA;Twombly T;Du C;Koh H;Li W;Meyerhardt JA;Wolpin BM;Giannakis M;Aguirre AJ;Bass AJ;Drew DA;Chan AT;Fuchs CS;Qian ZR;Ogino S
• 通讯作者: Ogino S

Tumor PDCD1LG2 (PD-L2) Expression and the Lymphocytic Reaction to Colorectal Cancer.

• DOI: 10.1158/2326-6066.cir-17-0122
• 发表时间: 2017-11
• 期刊: Cancer immunology research
• 影响因子: 10.1
• 作者: Masugi Y;Nishihara R;Hamada T;Song M;da Silva A;Kosumi K;Gu M;Shi Y;Li W;Liu L;Nevo D;Inamura K;Cao Y;Liao X;Nosho K;Chan AT;Giannakis M;Bass AJ;Hodi FS;Freeman GJ;Rodig SJ;Fuchs CS;Qian ZR;Nowak JA;Ogino S
• 通讯作者: Ogino S