Morphometrical and quantitative transcriptome analyses of C-C chemokine receptor 5 in functional structure of osteoclasts

破骨细胞功能结构中C-C趋化因子受体5的形态计量学和定量转录组分析

• 批准号: 16K20412
• 负责人: LEE JIWON
• 金额: $ 2.5万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16K20412/
• 关键词: osteoclast; osteoblast; chemokine receptor 5; bone metabolism; chemokine; bone; CCR5; RANKL; chemokine receptor; RNA-sequence; histomorphometry

项目成果

Requirement of CCR5, a co-receptor of HIV, for the functional cellular architecture of osteoclasts, providing experimental evidences for the direct association between loss of CCR5 and resistance to bone loss

CCR5（HIV 的共同受体）对破骨细胞功能性细胞结构的需求，为 CCR5 缺失与抗骨质流失之间的直接关联提供了实验证据

• 发表时间: 2017
• 作者: Lee JW;Inoue K;Uehara;S;Kobayashi Y;Imai Y;Iimura T
• 通讯作者: Iimura T

CCR5 is required for osteoclast function through regulating lysosomal vesicle trafficking

CCR5 通过调节溶酶体囊泡运输来实现破骨细胞功能

• 发表时间: 2018
• 作者: LEe JW;Iami Y;Iimura T
• 通讯作者: Iimura T

Shedding quantitative fluorescence light on novel regulatory mechanisms in skeletal biomedicine and biodentistry.

• DOI: 10.1016/j.jdsr.2016.04.005
• 发表时间: 2017-02
• 期刊: The Japanese dental science review
• 作者: Lee JW;Iimura T
• 通讯作者: Iimura T

The HIV co-receptor CCR5 regulates osteoclast function.

• DOI: 10.1038/s41467-017-02368-5
• 发表时间: 2017-12-20
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Lee JW;Hoshino A;Inoue K;Saitou T;Uehara S;Kobayashi Y;Ueha S;Matsushima K;Yamaguchi A;Imai Y;Iimura T
• 通讯作者: Iimura T

Journal of Oral Biosciences

口腔生物科学杂志

• DOI: 10.1016/j.job.2016.09.001
• 发表时间: 2017
• 期刊: Unveiling a rhythmic regulatory mode hidden in developmental tissue growth by fluorescence live imaging-based mathematical modeling
• 作者: Tadahiro Iimura;Ji-Won Lee
• 通讯作者: Ji-Won Lee